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Biomaterials for Tissue Engineering

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Cover of 'Biomaterials for Tissue Engineering'

Table of Contents

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    Book Overview
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    Chapter 1 Engineering Citric Acid-Based Porous Scaffolds for Bone Regeneration
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    Chapter 2 Multifunctional Self-Assembling Peptide-Based Nanostructures for Targeted Intracellular Delivery: Design, Physicochemical Characterization, and Biological Assessment
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    Chapter 3 Electrospinning Functionalized Polymers for Use as Tissue Engineering Scaffolds
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    Chapter 4 Low-Temperature Deposition Modeling of β-TCP Scaffolds with Controlled Bimodal Porosity
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    Chapter 5 Three-Dimensional Hydrogel-Based Culture to Study the Effects of Toxicants on Ovarian Follicles
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    Chapter 6 Layer-by-Layer Engineered Polymer Capsules for Therapeutic Delivery
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    Chapter 7 Controlling Fibrin Network Morphology, Polymerization, and Degradation Dynamics in Fibrin Gels for Promoting Tissue Repair
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    Chapter 8 Biofunctionalization of Poly(acrylamide) Gels
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    Chapter 9 Synthetic PEG Hydrogel for Engineering the Environment of Ovarian Follicles
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    Chapter 10 Engineering Human Neural Tissue by 3D Bioprinting
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    Chapter 11 High-Throughput Formation of Mesenchymal Stem Cell Spheroids and Entrapment in Alginate Hydrogels
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    Chapter 12 Crimped Electrospun Fibers for Tissue Engineering
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    Chapter 13 In Vitro Model of Macrophage-Biomaterial Interactions
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    Chapter 14 Synthesis of Self-Assembling Peptide-Based Hydrogels for Regenerative Medicine Using Solid-Phase Peptide Synthesis
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    Chapter 15 H2S Delivery from Aromatic Peptide Amphiphile Hydrogels
Attention for Chapter 7: Controlling Fibrin Network Morphology, Polymerization, and Degradation Dynamics in Fibrin Gels for Promoting Tissue Repair
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Chapter title
Controlling Fibrin Network Morphology, Polymerization, and Degradation Dynamics in Fibrin Gels for Promoting Tissue Repair
Chapter number 7
Book title
Biomaterials for Tissue Engineering
Published in
Methods in molecular biology, January 2018
DOI 10.1007/978-1-4939-7741-3_7
Pubmed ID
Book ISBNs
978-1-4939-7739-0, 978-1-4939-7741-3
Authors

Erin P. Sproul, Riley T. Hannan, Ashley C. Brown

Abstract

Fibrin is an integral part of the clotting cascade and is formed by polymerization of the soluble plasma protein fibrinogen. Following stimulation of the coagulation cascade, thrombin activates fibrinogen, which binds to adjacent fibrin(ogen) molecules resulting in the formation of an insoluble fibrin matrix. This fibrin network is the primary protein component in clots and subsequently provides a scaffold for infiltrating cells during tissue repair. Due to its role in hemostasis and tissue repair, fibrin has been used extensively as a tissue sealant. Clinically used fibrin tissue sealants require supraphysiological concentrations of fibrinogen and thrombin to achieve fast polymerization kinetics, which results in extremely dense fibrin networks that are inhibitory to cell infiltration. Therefore, there is much interest in developing fibrin-modifying strategies to achieve rapid polymerization dynamics while maintaining a network structure that promotes cell infiltration. The properties of fibrin-based materials can be finely controlled through techniques that modulate fibrin polymerization dynamics or through the inclusion of fibrin-modifying biomaterials. Here, we describe methods for characterizing fibrin network morphology, polymerization, and degradation (fibrinolysis) dynamics in fibrin constructs for achieving fast polymerization dynamics while promoting cell infiltration.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 31 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 26%
Student > Ph. D. Student 6 19%
Student > Bachelor 3 10%
Student > Master 2 6%
Unspecified 1 3%
Other 1 3%
Unknown 10 32%
Readers by discipline Count As %
Engineering 4 13%
Biochemistry, Genetics and Molecular Biology 4 13%
Chemical Engineering 3 10%
Agricultural and Biological Sciences 2 6%
Computer Science 1 3%
Other 5 16%
Unknown 12 39%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 January 2019.
All research outputs
#18,603,172
of 23,043,346 outputs
Outputs from Methods in molecular biology
#7,992
of 13,194 outputs
Outputs of similar age
#330,627
of 442,416 outputs
Outputs of similar age from Methods in molecular biology
#950
of 1,499 outputs
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So far Altmetric has tracked 13,194 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
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We're also able to compare this research output to 1,499 others from the same source and published within six weeks on either side of this one. This one is in the 20th percentile – i.e., 20% of its contemporaries scored the same or lower than it.