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Biomaterials for Tissue Engineering

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Cover of 'Biomaterials for Tissue Engineering'

Table of Contents

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    Book Overview
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    Chapter 1 Engineering Citric Acid-Based Porous Scaffolds for Bone Regeneration
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    Chapter 2 Multifunctional Self-Assembling Peptide-Based Nanostructures for Targeted Intracellular Delivery: Design, Physicochemical Characterization, and Biological Assessment
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    Chapter 3 Electrospinning Functionalized Polymers for Use as Tissue Engineering Scaffolds
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    Chapter 4 Low-Temperature Deposition Modeling of β-TCP Scaffolds with Controlled Bimodal Porosity
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    Chapter 5 Three-Dimensional Hydrogel-Based Culture to Study the Effects of Toxicants on Ovarian Follicles
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    Chapter 6 Layer-by-Layer Engineered Polymer Capsules for Therapeutic Delivery
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    Chapter 7 Controlling Fibrin Network Morphology, Polymerization, and Degradation Dynamics in Fibrin Gels for Promoting Tissue Repair
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    Chapter 8 Biofunctionalization of Poly(acrylamide) Gels
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    Chapter 9 Synthetic PEG Hydrogel for Engineering the Environment of Ovarian Follicles
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    Chapter 10 Engineering Human Neural Tissue by 3D Bioprinting
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    Chapter 11 High-Throughput Formation of Mesenchymal Stem Cell Spheroids and Entrapment in Alginate Hydrogels
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    Chapter 12 Crimped Electrospun Fibers for Tissue Engineering
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    Chapter 13 In Vitro Model of Macrophage-Biomaterial Interactions
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    Chapter 14 Synthesis of Self-Assembling Peptide-Based Hydrogels for Regenerative Medicine Using Solid-Phase Peptide Synthesis
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    Chapter 15 H2S Delivery from Aromatic Peptide Amphiphile Hydrogels
Attention for Chapter 6: Layer-by-Layer Engineered Polymer Capsules for Therapeutic Delivery
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Chapter title
Layer-by-Layer Engineered Polymer Capsules for Therapeutic Delivery
Chapter number 6
Book title
Biomaterials for Tissue Engineering
Published in
Methods in molecular biology, January 2018
DOI 10.1007/978-1-4939-7741-3_6
Pubmed ID
Book ISBNs
978-1-4939-7739-0, 978-1-4939-7741-3
Authors

Rona Chandrawati, Chandrawati, Rona

Abstract

Polymer capsules fabricated via layer-by-layer (LbL) assembly have emerged as promising carriers for therapeutic delivery. The versatile assembly technique allows an extensive choice of materials to be incorporated as constituents of the multilayers, which therefore endow capsules with specific properties and functionalities. This chapter describes protocols for fabrication of LbL-engineered poly(methacrylic acid) (PMA) capsules for applications in gene delivery, including (1) synthesis of building blocks, (2) cargo encapsulation, (3) multilayer film formation, (4) surface modification, and (5) cross-linking of multilayer films and dissolution of particle templates. DNA is adsorbed onto positively charged silica particle templates, followed by formation of polymer films via hydrogen-bonded multilayers of thiol-functionalized PMA and poly(N-vinylpyrrolidone) (PVP). The outer polymer membranes can be surface modified with copolymers of PMA and poly(ethylene glycol) (PEG). Upon film stabilization and dissolution of particle templates, disulfide-cross-linked DNA-loaded PMA capsules are obtained, which serve as therapeutic carriers that can degrade and facilitate cargo release in intracellular reducing environment.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 15 100%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 4 27%
Student > Master 3 20%
Student > Ph. D. Student 3 20%
Researcher 2 13%
Student > Bachelor 1 7%
Other 1 7%
Unknown 1 7%
Readers by discipline Count As %
Chemistry 3 20%
Chemical Engineering 2 13%
Engineering 2 13%
Materials Science 2 13%
Nursing and Health Professions 1 7%
Other 4 27%
Unknown 1 7%