Chapter title |
Degeneration of Select Motor and Limbic Nuclei of the Thalamus in Huntington's Disease (HD).
|
---|---|
Chapter number | 4 |
Book title |
The Neuropathology of Huntington’s Disease: Classical Findings, Recent Developments and Correlation to Functional Neuroanatomy
|
Published in |
Advances in anatomy embryology and cell biology, January 2015
|
DOI | 10.1007/978-3-319-19285-7_4 |
Pubmed ID | |
Book ISBNs |
978-3-31-919284-0, 978-3-31-919285-7
|
Authors |
Rüb, Udo, Vonsattel, Jean Paul G, Heinsen, Helmut, Korf, Horst-Werner, Udo Rüb, Jean Paul G. Vonsattel, Helmut Heinsen, Horst-Werner Korf |
Abstract |
Although early neuropathological studies reported degenerative features in subcortical brain regions of HD patients (e.g., pallidum, subthalamic nucleus, substantia nigra, claustrum, amygdala) including the thalamus (e.g., global atrophy and volume loss of the thalamus; thalamic astrogliosis; reduced density of microneurons in its cerebellar territory, the ventrolateral nucleus; astrogliosis in the centromedian and parafascicular nuclei; shrinkage of the centromedian nucleus and its nerve cells) (see Chap. 1 ) (Borrell-Pagès et al. 2006; Dom et al. 1976; Finkbeiner and Mitra 2008; Lange and Aulich 1986; Lange et al. 1976; McCaughey 1961; McLardy 1948; Pfeiffer 1913; Terplan 1924; Vonsattel 2008; Vonsattel and DiFiglia 1998; Vonsattel et al. 1985; Walker 2007a, b), the involvement of the thalamus and the extent of its degeneration in HD have been neglected in more recent investigations. Therefore, the affection of the thalamic nuclei is currently not among the established degenerative features of HD. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 1 | 100% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 1 | 100% |