Chapter title |
NAFLD Related-HCC: The Relationship with Metabolic Disorders
|
---|---|
Chapter number | 5 |
Book title |
Obesity, Fatty Liver and Liver Cancer
|
Published in |
Advances in experimental medicine and biology, January 2018
|
DOI | 10.1007/978-981-10-8684-7_5 |
Pubmed ID | |
Book ISBNs |
978-9-81-108683-0, 978-9-81-108684-7
|
Authors |
Xiang Zhang, Zhang, Xiang |
Abstract |
Obesity increases death rates of all cancers including non-alcoholic fatty liver disease (NAFLD)-related hepatocellular carcinoma (NAFLD-HCC). NAFLD is considered as hepatic manifestation of metabolic syndrome and is a multi-system disease. Recent prevalence studies have intensively reported the association of obesity, metabolic risk factors and HCC incidence and mortality. Mechanistic studies suggested that immune response, PI3K/AKT/mTOR/PTEN pathway, mitochondrial dysfunction and genetic alterations are important mediators in the progression of NAFLD-HCC from metabolic disorder. In this book chapter, we attempt to collate current research on NAFLD-HCC that lead to our understandings on how metabolic disorders may intersect with cancer development. We also discussed the prevention options of NAFLD-HCC in view of obesity and metabolic disorder. These studies have extended our knowledge on the complicated mechanism of NAFLD and HCC, and provided the prevention options of NAFLD-HCC in patients with obesity and metabolic diseases. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 36 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 7 | 19% |
Student > Ph. D. Student | 5 | 14% |
Student > Doctoral Student | 3 | 8% |
Researcher | 3 | 8% |
Student > Postgraduate | 2 | 6% |
Other | 5 | 14% |
Unknown | 11 | 31% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 8 | 22% |
Biochemistry, Genetics and Molecular Biology | 7 | 19% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 6% |
Immunology and Microbiology | 2 | 6% |
Computer Science | 1 | 3% |
Other | 3 | 8% |
Unknown | 13 | 36% |