Chapter title |
Fetal Origins of Hypertension
|
---|---|
Chapter number | 5 |
Book title |
Developmental Origins of Health and Disease (DOHaD)
|
Published in |
Advances in experimental medicine and biology, January 2018
|
DOI | 10.1007/978-981-10-5526-3_5 |
Pubmed ID | |
Book ISBNs |
978-9-81-105525-6, 978-9-81-105526-3
|
Authors |
Yuichiro Arima, Koichi Nishiyama, Yasuhiro Izumiya, Koichi Kaikita, Seiji Hokimoto, Kenichi Tsujita, Arima, Yuichiro, Nishiyama, Koichi, Izumiya, Yasuhiro, Kaikita, Koichi, Hokimoto, Seiji, Tsujita, Kenichi |
Abstract |
Hypertension is a common noncommunicable disease. According to the World Health Organization, 1.13 billion people were suffering from hypertension in the year 2015. High blood pressure, hypertension, has a multifactorial etiology. Arterial atherosclerotic changes, systolic or diastolic dysfunction of the heart, and other noncardiac factors are involved. Epidemiological evidence has revealed that perinatal growth disturbance elevates the prevalence of hypertension. However, the specific effects of developmental disturbances on the pathological process of hypertension are poorly understood. Recently, it has become apparent that the perinatal period plays many essential roles in cardiovascular development. In this chapter, we focus on the perinatal development of the cardiovascular system, especially in murine models. Individual organs, blood, blood vessels, and the heart show unique growth characteristics during this period. We also introduce evidence from related clinical studies regarding the developmental origins of hypertension. Finally, evidence from several animal models is presented to reveal the effects of developmental disturbance or stress on arterial pathology. Improving our understanding of both developmental events and the results of clinical studies will give fresh insight into the fetal origins of hypertension. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Netherlands | 1 | 2% |
Unknown | 47 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 10 | 21% |
Student > Ph. D. Student | 7 | 15% |
Student > Bachelor | 4 | 8% |
Professor | 3 | 6% |
Professor > Associate Professor | 3 | 6% |
Other | 10 | 21% |
Unknown | 11 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 18 | 38% |
Agricultural and Biological Sciences | 4 | 8% |
Psychology | 4 | 8% |
Biochemistry, Genetics and Molecular Biology | 3 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
Other | 5 | 10% |
Unknown | 12 | 25% |