Chapter title |
Risk of Neurodevelopmental Disease by Paternal Aging: A Possible Influence of Epigenetic Alteration in Sperm
|
---|---|
Chapter number | 8 |
Book title |
Developmental Origins of Health and Disease (DOHaD)
|
Published in |
Advances in experimental medicine and biology, January 2018
|
DOI | 10.1007/978-981-10-5526-3_8 |
Pubmed ID | |
Book ISBNs |
978-9-81-105525-6, 978-9-81-105526-3
|
Authors |
Ryuichi Kimura, Kaichi Yoshizaki, Noriko Osumi, Kimura, Ryuichi, Yoshizaki, Kaichi, Osumi, Noriko |
Abstract |
Sincethe theory of DOHaD has been thrown in the spotlight, most attention has focused on environmental effects of the uterus on developing embryos/fetuses. However, the ontogenesis traces back to gametogenesis. Compared to oogenesis, spermatogenesis goes through far more cell divisions and is therefore more prone to genetic variation and epigenetic alterations. This article will mainly discuss recent findings about the effects of the advanced paternal age on the next generation, in relation to the onset of psychiatric disorders such as autism spectrum disorder. We would like to advocate for further exploration on the DOHaD theory in a wider view. |
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Mendeley readers
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