Chapter title |
Analysis of Progranulin-Mediated Akt and MAPK Activation
|
---|---|
Chapter number | 9 |
Book title |
Progranulin
|
Published in |
Methods in molecular biology, January 2018
|
DOI | 10.1007/978-1-4939-8559-3_9 |
Pubmed ID | |
Book ISBNs |
978-1-4939-8557-9, 978-1-4939-8559-3
|
Authors |
Shi-Qiong Xu, Simone Buraschi, Ryuta Tanimoto, Manuela Stefanello, Antonino Belfiore, Renato V. Iozzo, Andrea Morrione, Xu, Shi-Qiong, Buraschi, Simone, Tanimoto, Ryuta, Stefanello, Manuela, Belfiore, Antonino, Iozzo, Renato V., Morrione, Andrea |
Abstract |
Progranulin has emerged in recent years as an important regulator of various biological functions including cell proliferation, wound healing, motility, and protection from apoptosis. Progranulin is also critical for transformation as established in several cancer models.Progranulin biological responses elicit through the activation of the Akt and MAPK pathways, which are critical for progranulin downstream signaling.In this chapter various experimental approaches aiming at detecting progranulin-mediated Akt and MAPK activation will be discussed. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 5 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Professor | 1 | 20% |
Professor > Associate Professor | 1 | 20% |
Student > Bachelor | 1 | 20% |
Unknown | 2 | 40% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 1 | 20% |
Unknown | 4 | 80% |