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Immunotoxicity Testing

Overview of attention for book
Cover of 'Immunotoxicity Testing'

Table of Contents

  1. Altmetric Badge
    Book Overview
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    Chapter 1 Immunotoxicology: A Brief History
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    Chapter 2 Clinical Immunotoxicology
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    Chapter 3 Investigative Immunotoxicology
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    Chapter 4 Developmental Immunotoxicity (DIT) Testing: Current Recommendations and the Future of DIT Testing
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    Chapter 5 Markers of Inflammation
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    Chapter 6 The Sheep Erythrocyte T-Dependent Antibody Response (TDAR)
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    Chapter 7 Methylated Bovine Serum Albumin (mBSA)-Induced Delayed-Type Hypersensitivity in Mice
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    Chapter 8 Use of the LLNA:BrdU-ELISA for Skin Sensitization Hazard Assessment
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    Chapter 9 Host Resistance Assays
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    Chapter 10 Enhanced Histopathology Evaluation of Lymphoid Organs
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    Chapter 11 Tumor Challenges in Immunotoxicity Testing
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    Chapter 12 Flow Cytometry for the Immunotoxicologist
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    Chapter 13 Evaluation of Cell-Mediated Immune Function Using the Cytotoxic T-Lymphocyte Assay
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    Chapter 14 Evaluation of Cell Proliferation and Apoptosis in Immunotoxicity Testing
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    Chapter 15 Natural Killer (NK) Cell Assays in Immunotoxicity Testing
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    Chapter 16 Dendritic Cell Assays
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    Chapter 17 Evaluating Macrophages in Immunotoxicity Testing
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    Chapter 18 Evaluating Cytokines in Immunotoxicity Testing
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    Chapter 19 Functional Assays of Hematopoietic Stem Cells in Toxicology Research
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    Chapter 20 CD4 + T Cell Differentiation and Activation
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    Chapter 21 Isolation and Identification of Innate Lymphoid Cells (ILCs) for Immunotoxicity Testing
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    Chapter 22 Evaluating Antigen-Specific IgE Using the Rat Basophil Leukemia Cell (RBL) Assay
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    Chapter 23 Challenges for Integrating Immunotoxicology into the Twenty-First-Century Toxicology Testing Paradigm
Attention for Chapter 15: Natural Killer (NK) Cell Assays in Immunotoxicity Testing
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  • Above-average Attention Score compared to outputs of the same age and source (60th percentile)

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Chapter title
Natural Killer (NK) Cell Assays in Immunotoxicity Testing
Chapter number 15
Book title
Immunotoxicity Testing
Published in
Methods in molecular biology, January 2018
DOI 10.1007/978-1-4939-8549-4_15
Pubmed ID
29882143
Book ISBNs
978-1-4939-8548-7, 978-1-4939-8549-4
Authors

Qing Li, Li, Qing

Abstract

It is well known that natural killer (NK) cells are involved in defense against viruses and some tumors. NK cells kill target cells by the directed release of cytolytic granules that contain perforin, granzymes, and granulysin. It is increasingly important to evaluate NK cell function in immunotoxicity testing. NK cell function can be evaluated by determining cytolytic activity against target tumor cells by the 51Cr-release assay and also by determining the number of NK cells in peripheral blood in humans and in the spleen in animals using flow cytometry. Recently, the intracellular levels of perforin, granzymes, and granulysin determined by flow cytometry have also been used in the evaluation of NK cell function. In addition, chemical-induced apoptosis in NK cells also has been applied to evaluate the immunotoxicity of chemicals. This chapter will describe the methods for NK cell assays in immunotoxicity testing.

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X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
 Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 17 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 2 12%
Unspecified 1 6%
Lecturer 1 6%
Student > Ph. D. Student 1 6%
Professor 1 6%
Other 2 12%
Unknown 9 53%
Readers by discipline Count As %
Medicine and Dentistry 2 12%
Unspecified 1 6%
Immunology and Microbiology 1 6%
Biochemistry, Genetics and Molecular Biology 1 6%
Social Sciences 1 6%
Other 1 6%
Unknown 10 59%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 June 2018.
All research outputs
#15,010,626
of 23,090,520 outputs
Outputs from Methods in molecular biology
#4,749
of 13,206 outputs
Outputs of similar age
#256,083
of 442,634 outputs
Outputs of similar age from Methods in molecular biology
#508
of 1,499 outputs
Altmetric has tracked 23,090,520 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,206 research outputs from this source. They receive a mean Attention Score of 3.4. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 442,634 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1,499 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.

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