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Immunotoxicity Testing

Overview of attention for book
Cover of 'Immunotoxicity Testing'

Table of Contents

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    Book Overview
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    Chapter 1 Immunotoxicology: A Brief History
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    Chapter 2 Clinical Immunotoxicology
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    Chapter 3 Investigative Immunotoxicology
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    Chapter 4 Developmental Immunotoxicity (DIT) Testing: Current Recommendations and the Future of DIT Testing
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    Chapter 5 Markers of Inflammation
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    Chapter 6 The Sheep Erythrocyte T-Dependent Antibody Response (TDAR)
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    Chapter 7 Methylated Bovine Serum Albumin (mBSA)-Induced Delayed-Type Hypersensitivity in Mice
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    Chapter 8 Use of the LLNA:BrdU-ELISA for Skin Sensitization Hazard Assessment
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    Chapter 9 Host Resistance Assays
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    Chapter 10 Enhanced Histopathology Evaluation of Lymphoid Organs
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    Chapter 11 Tumor Challenges in Immunotoxicity Testing
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    Chapter 12 Flow Cytometry for the Immunotoxicologist
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    Chapter 13 Evaluation of Cell-Mediated Immune Function Using the Cytotoxic T-Lymphocyte Assay
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    Chapter 14 Evaluation of Cell Proliferation and Apoptosis in Immunotoxicity Testing
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    Chapter 15 Natural Killer (NK) Cell Assays in Immunotoxicity Testing
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    Chapter 16 Dendritic Cell Assays
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    Chapter 17 Evaluating Macrophages in Immunotoxicity Testing
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    Chapter 18 Evaluating Cytokines in Immunotoxicity Testing
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    Chapter 19 Functional Assays of Hematopoietic Stem Cells in Toxicology Research
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    Chapter 20 CD4 + T Cell Differentiation and Activation
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    Chapter 21 Isolation and Identification of Innate Lymphoid Cells (ILCs) for Immunotoxicity Testing
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    Chapter 22 Evaluating Antigen-Specific IgE Using the Rat Basophil Leukemia Cell (RBL) Assay
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    Chapter 23 Challenges for Integrating Immunotoxicology into the Twenty-First-Century Toxicology Testing Paradigm
Attention for Chapter 5: Markers of Inflammation
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#14 of 13,961)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

28 news outlets
1 YouTube creator


15 Dimensions

Readers on

588 Mendeley
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Chapter title
Markers of Inflammation
Chapter number 5
Book title
Immunotoxicity Testing
Published in
Methods in molecular biology, January 2018
DOI 10.1007/978-1-4939-8549-4_5
Pubmed ID
Book ISBNs
978-1-4939-8548-7, 978-1-4939-8549-4

Dori R. Germolec, Kelly A. Shipkowski, Rachel P. Frawley, Ellen Evans, Germolec, Dori R., Shipkowski, Kelly A., Frawley, Rachel P., Evans, Ellen


Inflammation is a complex and necessary component of the response to biological, chemical, or physical stimuli, and the cellular and molecular events that initiate and regulate the interactions between the various players in the inflammatory process remain a source of ongoing investigation. In the acute phase of the inflammatory response, cells of the immune system migrate to the site of injury in a carefully orchestrated sequence of events that is facilitated by soluble mediators such as cytokines, chemokines, and acute-phase proteins. Depending on the degree of injury, this acute phase may be sufficient to resolve the damage and initiate healing processes. Persistent inflammation, either as a result of prolonged exposure to stimulation or an inappropriate reaction against self-molecules, can lead to the chronic phase, in which tissue damage and fibrosis can occur. Chronic inflammation has been reported to contribute to numerous diseases, including arthritis, asthma, atherosclerosis, autoimmune diseases, diabetes, and cancer, and to conditions of aging. Hematology and clinical chemistry data from standard toxicology studies can provide an initial indication of the presence and sometimes the location of inflammation. These data may suggest more specific immune function assays that are necessary to determine the presence and/or mechanism(s) of immunomodulation. Although changes in hematology dynamics, acute-phase proteins, complement factors, and cytokines are common to virtually all inflammatory conditions, and can be measured by a variety of techniques, individual biomarkers have yet to be strongly associated with specific pathologic events. Thus, although sensitive indicators of inflammation, these factors generally lack the specificity to identify the offending cause. The profile seen in a given inflammatory condition is dependent on the severity, chronicity, and mechanisms involved in the inflammatory process, as well as the species and the capacity of the individual's immune system to respond and adapt.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 588 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 588 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 80 14%
Student > Master 62 11%
Student > Ph. D. Student 43 7%
Researcher 25 4%
Student > Doctoral Student 23 4%
Other 66 11%
Unknown 289 49%
Readers by discipline Count As %
Medicine and Dentistry 83 14%
Biochemistry, Genetics and Molecular Biology 62 11%
Agricultural and Biological Sciences 29 5%
Pharmacology, Toxicology and Pharmaceutical Science 27 5%
Immunology and Microbiology 27 5%
Other 65 11%
Unknown 295 50%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 224. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 November 2023.
All research outputs
of 24,855,923 outputs
Outputs from Methods in molecular biology
of 13,961 outputs
Outputs of similar age
of 453,890 outputs
Outputs of similar age from Methods in molecular biology
of 1,485 outputs
Altmetric has tracked 24,855,923 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 13,961 research outputs from this source. They receive a mean Attention Score of 3.5. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 453,890 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 1,485 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.