Chapter title |
AlzPathway, an Updated Map of Curated Signaling Pathways: Towards Deciphering Alzheimer's Disease Pathogenesis.
|
---|---|
Chapter number | 25 |
Book title |
Systems Biology of Alzheimer's Disease
|
Published in |
Methods in molecular biology, January 2016
|
DOI | 10.1007/978-1-4939-2627-5_25 |
Pubmed ID | |
Book ISBNs |
978-1-4939-2626-8, 978-1-4939-2627-5
|
Authors |
Ogishima, Soichi, Mizuno, Satoshi, Kikuchi, Masataka, Miyashita, Akinori, Kuwano, Ryozo, Tanaka, Hiroshi, Nakaya, Jun, Soichi Ogishima, Satoshi Mizuno, Masataka Kikuchi, Akinori Miyashita, Ryozo Kuwano, Hiroshi Tanaka, Jun Nakaya |
Editors |
Juan I. Castrillo, Stephen G. Oliver |
Abstract |
Alzheimer's disease (AD) is a complex neurodegenerative disorder in which loss of neurons and synaptic function causes dementia in the elderly. To clarify AD pathogenesis and develop drugs for AD, thousands of studies have elucidated signaling pathways involved. However, knowledge of AD signaling pathways has not been compiled as a pathway map. In this chapter, we introduce the manual construction of a pathway map in AD which we call "AlzPathway", that comprehensively catalogs signaling pathways in the field of AD. We have collected and manually curated over 100 review articles related to AD, and have built the AD pathway map. AlzPathway is currently composed of thousands of molecules and reactions in neurons, brain blood barrier, presynaptic, postsynaptic, astrocyte, and microglial cells, with their cellular localizations. AlzPathway provides a systems-biology platform of comprehensive AD signaling and related pathways which is expected to contribute to clarification of AD pathogenesis and AD drug development. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 3 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 2 | 67% |
Members of the public | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 3% |
Germany | 1 | 3% |
Luxembourg | 1 | 3% |
Unknown | 28 | 90% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 7 | 23% |
Other | 5 | 16% |
Student > Master | 5 | 16% |
Student > Ph. D. Student | 5 | 16% |
Student > Doctoral Student | 1 | 3% |
Other | 4 | 13% |
Unknown | 4 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 6 | 19% |
Agricultural and Biological Sciences | 5 | 16% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 13% |
Biochemistry, Genetics and Molecular Biology | 3 | 10% |
Neuroscience | 3 | 10% |
Other | 4 | 13% |
Unknown | 6 | 19% |