Chapter title |
A Practical Guide for Exploring Opportunities of Repurposing Drugs for CNS Diseases in Systems Biology.
|
---|---|
Chapter number | 33 |
Book title |
Systems Biology of Alzheimer's Disease
|
Published in |
Methods in molecular biology, January 2016
|
DOI | 10.1007/978-1-4939-2627-5_33 |
Pubmed ID | |
Book ISBNs |
978-1-4939-2626-8, 978-1-4939-2627-5
|
Authors |
Hongkang Mei, Gang Feng, Jason Zhu, Simon Lin, Yang Qiu, Yue Wang, Tian Xia |
Editors |
Juan I. Castrillo, Stephen G. Oliver |
Abstract |
Systems biology has shown its potential in facilitating pathway-focused therapy development for central nervous system (CNS) diseases. An integrated network can be utilized to explore the multiple disease mechanisms and to discover repositioning opportunities. This review covers current therapeutic gaps for CNS diseases and the role of systems biology in pharmaceutical industry. We conclude with a Multiple Level Network Modeling (MLNM) example to illustrate the great potential of systems biology for CNS diseases. The system focuses on the benefit and practical applications in pathway centric therapy and drug repositioning. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 18 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 6 | 33% |
Student > Master | 2 | 11% |
Student > Ph. D. Student | 2 | 11% |
Other | 1 | 6% |
Lecturer | 1 | 6% |
Other | 2 | 11% |
Unknown | 4 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 5 | 28% |
Medicine and Dentistry | 3 | 17% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 11% |
Agricultural and Biological Sciences | 2 | 11% |
Computer Science | 1 | 6% |
Other | 2 | 11% |
Unknown | 3 | 17% |