Chapter title |
Host Resistance Assays
|
---|---|
Chapter number | 9 |
Book title |
Immunotoxicity Testing
|
Published in |
Methods in molecular biology, January 2018
|
DOI | 10.1007/978-1-4939-8549-4_9 |
Pubmed ID | |
Book ISBNs |
978-1-4939-8548-7, 978-1-4939-8549-4
|
Authors |
Stefanie C. M. Burleson, Wendy Jo Freebern, Florence G. Burleson, Gary R. Burleson, Victor J. Johnson, Robert W. Luebke |
Abstract |
The goal of immunotoxicity testing is to obtain data useful for immunotoxicity safety assessment. Guidance in the performance of immunotoxicity safety evaluations is provided in documents from the US EPA for chemicals and the ICH S8 document for pharmaceuticals. The ICH S8 document outlines a tiered approach that includes (1) standard toxicity studies with associated hematology, immune system organ weights, and histopathology data; (2) functional assays, such as cytotoxic T lymphocyte (CTL) assays, natural killer (NK) cell assays, respiratory burst, phagocytosis, and T-cell-dependent antibody response (TDAR) assays; and (3) host resistance assays. Host resistance assays are considered the gold standard in immunotoxicity testing and provide a critical overview of the extent to which innate, adaptive, and homeostatic regulatory immune functions are integrated to protect the host. Both comprehensive and targeted host resistance assays are available, each with distinct advantages. This chapter serves to provide a general overview of the various assays that may be used, as well as a summary of procedures. |
X Demographics
Geographical breakdown
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 13 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 4 | 31% |
Other | 2 | 15% |
Lecturer | 1 | 8% |
Professor | 1 | 8% |
Student > Ph. D. Student | 1 | 8% |
Other | 2 | 15% |
Unknown | 2 | 15% |
Readers by discipline | Count | As % |
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Pharmacology, Toxicology and Pharmaceutical Science | 2 | 15% |
Biochemistry, Genetics and Molecular Biology | 2 | 15% |
Medicine and Dentistry | 2 | 15% |
Nursing and Health Professions | 1 | 8% |
Social Sciences | 1 | 8% |
Other | 1 | 8% |
Unknown | 4 | 31% |