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Huntington’s Disease

Overview of attention for book
Huntington’s Disease
Springer New York

Table of Contents

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    Book Overview
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    Chapter 1 Stereological Methods to Quantify Cell Loss in the Huntington’s Disease Human Brain
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    Chapter 2 Assessing Autophagic Activity and Aggregate Formation of Mutant Huntingtin in Mammalian Cells
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    Chapter 3 A Filter Retardation Assay Facilitates the Detection and Quantification of Heat-Stable, Amyloidogenic Mutant Huntingtin Aggregates in Complex Biosamples
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    Chapter 4 Cellular Models: HD Patient-Derived Pluripotent Stem Cells
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    Chapter 6 Mouse Models of Huntington’s Disease
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    Chapter 8 Automated Operant Assessments of Huntington’s Disease Mouse Models
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    Chapter 10 Murine Models of Huntington’s Disease for Evaluating Therapeutics
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    Chapter 11 Generating Excitotoxic Lesion Models of Huntington’s Disease
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    Chapter 12 Large-Brained Animal Models of Huntington’s Disease: Sheep
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    Chapter 14 Nonhuman Primate Models of Huntington’s Disease and Their Application in Translational Research
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    Chapter 15 In Vivo Multidimensional Brain Imaging in Huntington’s Disease Animal Models
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    Chapter 16 Magnetic Resonance Imaging in Huntington’s Disease
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    Chapter 17 Biofluid Biomarkers in Huntington’s Disease
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    Chapter 18 Assessing and Modulating Kynurenine Pathway Dynamics in Huntington’s Disease: Focus on Kynurenine 3-Monooxygenase
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    Chapter 20 Using Genomic Data to Find Disease-Modifying Loci in Huntington’s Disease (HD)
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    Chapter 22 Methods for Assessing DNA Repair and Repeat Expansion in Huntington’s Disease
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    Chapter 23 Translating Antisense Technology into a Treatment for Huntington’s Disease
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    Chapter 26 Dissection and Preparation of Human Primary Fetal Ganglionic Eminence Tissue for Research and Clinical Applications
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    Chapter 28 Quality Assessment and Production of Human Cells for Clinical Use
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    Chapter 29 Erratum to: Large-Brained Animal Models of Huntington’s Disease: Sheep
Attention for Chapter: Nonmammalian Models of Huntington’s Disease
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Chapter title
Nonmammalian Models of Huntington’s Disease
Book title
Huntington’s Disease
Published in
Methods in molecular biology, January 2018
DOI 10.1007/978-1-4939-7825-0_5
Pubmed ID
Book ISBNs
978-1-4939-7824-3, 978-1-4939-7825-0
Authors

Anjalika Chongtham, Brett Barbaro, Tomas Filip, Adeela Syed, Weijian Huang, Marianne R. Smith, J. Lawrence Marsh

Abstract

Flies, worms, yeast and more recently zebra fish have all been engineered to express expanded polyglutamine repeat versions of Huntingtin with various resulting pathologies including early death, neurodegeneration, and loss of motor function. Each of these models present particular features that make it useful in studying the mechanisms of polyglutamine pathology. However, one particular unbiased readout of mHTT pathology is functional loss of motor control. Loss of motor control is prominent in patients, but it remains unresolved whether pathogenic symptoms in patients result from overt degeneration and loss of neurons or from malfunctioning of surviving neurons as the pathogenic insult builds up. This is why a functional assay such as motor control can be uniquely powerful in revealing early as well as late neurological deficits and does not rely on assumptions such as that the level of inclusions or the degree of neuronal loss can be equated with the level of pathology. Drosophila is well suited for such assays because it contains a functioning nervous system with many parallels to the human condition. In addition, the ability to readily express mHTT transgenes in different tissues and subsets of neurons allows one the possibility of isolating a particular effect to a subset of neurons where one can correlate subcellular events in response to mHTT challenge with pathology at both the cellular and organismal levels. Here we describe methods to monitor the degree of motor function disruption in Drosophila models of HD and we include a brief summary of other nonmammalian models of HD and discussion of their unique strengths.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 16 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 25%
Student > Master 3 19%
Other 2 13%
Student > Bachelor 1 6%
Unspecified 1 6%
Other 1 6%
Unknown 4 25%
Readers by discipline Count As %
Neuroscience 5 31%
Agricultural and Biological Sciences 3 19%
Biochemistry, Genetics and Molecular Biology 1 6%
Veterinary Science and Veterinary Medicine 1 6%
Unspecified 1 6%
Other 1 6%
Unknown 4 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 June 2018.
All research outputs
#19,015,492
of 23,577,654 outputs
Outputs from Methods in molecular biology
#8,199
of 13,410 outputs
Outputs of similar age
#333,752
of 444,928 outputs
Outputs of similar age from Methods in molecular biology
#942
of 1,483 outputs
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So far Altmetric has tracked 13,410 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
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