Huntington’s Disease
Springer New York
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Attention Score in Context
| Chapter title |
Assessing and Modulating Kynurenine Pathway Dynamics in Huntington’s Disease: Focus on Kynurenine 3-Monooxygenase
|
|---|---|
| Chapter number | 18 |
| Book title |
Huntington’s Disease
|
| Published in |
Methods in molecular biology, January 2018
|
| DOI | 10.1007/978-1-4939-7825-0_18 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-7824-3, 978-1-4939-7825-0
|
| Authors |
Korrapati V. Sathyasaikumar, Carlo Breda, Robert Schwarcz, Flaviano Giorgini, Sathyasaikumar, Korrapati V., Breda, Carlo, Schwarcz, Robert, Giorgini, Flaviano |
| Abstract |
The link between disturbances in kynurenine pathway (KP) metabolism and Huntington's disease (HD) pathogenesis has been explored for a number of years. Several novel genetic and pharmacological tools have recently been developed to modulate key regulatory steps in the KP such as the reaction catalyzed by the enzyme kynurenine 3-monooxygenase (KMO). This insight has offered new options for exploring the mechanistic link between this metabolic pathway and HD, and provided novel opportunities for the development of candidate drug-like compounds. Here, we present an overview of the field, focusing on some novel approaches for interrogating the pathway experimentally. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 12 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Postgraduate | 3 | 25% |
| Student > Master | 2 | 17% |
| Researcher | 2 | 17% |
| Student > Ph. D. Student | 1 | 8% |
| Student > Bachelor | 1 | 8% |
| Other | 0 | 0% |
| Unknown | 3 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 3 | 25% |
| Neuroscience | 3 | 25% |
| Computer Science | 1 | 8% |
| Medicine and Dentistry | 1 | 8% |
| Unknown | 4 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 June 2018.
All research outputs
#20,518,141
of 23,085,832 outputs
Outputs from Methods in molecular biology
#9,974
of 13,205 outputs
Outputs of similar age
#378,465
of 442,628 outputs
Outputs of similar age from Methods in molecular biology
#1,194
of 1,499 outputs
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