↓ Skip to main content
What is this page? Embed badge

Coordinating Organismal Physiology Through the Unfolded Protein Response

Overview of attention for book
Cover of 'Coordinating Organismal Physiology Through the Unfolded Protein Response'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 The Unfolded Protein Response in the Immune Cell Development: Putting the Caretaker in the Driving Seat
  3. Altmetric Badge
    Chapter 2 Mitochondria-Associated Membranes and ER Stress
  4. Altmetric Badge
    Chapter 36 Driving Cancer Tumorigenesis and Metastasis Through UPR Signaling
  5. Altmetric Badge
    Chapter 38 Cell Non-autonomous UPRER Signaling
  6. Altmetric Badge
    Chapter 41 Coordinating Organismal Metabolism During Protein Misfolding in the ER Through the Unfolded Protein Response
  7. Altmetric Badge
    Chapter 52 ER Stress and Neurodegenerative Disease: A Cause or Effect Relationship?
  8. Altmetric Badge
    Chapter 54 ER Protein Quality Control and the Unfolded Protein Response in the Heart
  9. Altmetric Badge
    Chapter 56 Adapting Secretory Proteostasis and Function Through the Unfolded Protein Response
Attention for Chapter 52: ER Stress and Neurodegenerative Disease: A Cause or Effect Relationship?
Altmetric Badge

Mentioned by

twitter
1 X user

Readers on

mendeley
50 Mendeley
citeulike
1 CiteULike
Summary X
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Chapter title
ER Stress and Neurodegenerative Disease: A Cause or Effect Relationship?
Chapter number 52
Book title
Coordinating Organismal Physiology Through the Unfolded Protein Response
Published in
Current topics in microbiology and immunology, January 2017
DOI 10.1007/82_2017_52
Pubmed ID
28864830
Book ISBNs
978-3-31-978529-5, 978-3-31-978530-1
Authors

Felipe Cabral-Miranda, Claudio Hetz, Cabral-Miranda, Felipe, Hetz, Claudio

Abstract

The accumulation of protein aggregates has a fundamental role in the patophysiology of distinct neurodegenerative diseases. This phenomenon may have a common origin, where disruption of intracellular mechanisms related to protein homeostasis (here termed proteostasis) control during aging may result in abnormal protein aggregation. The unfolded protein response (UPR) embodies a major element of the proteostasis network triggered by endoplasmic reticulum (ER) stress. Chronic ER stress may operate as possible mechanism of neurodegenerative and synaptic dysfunction, and in addition contribute to the abnormal aggregation of key disease-related proteins. In this article we overview the most recent findings suggesting a causal role of ER stress in neurodegenerative diseases.

View on publisher site
X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
 Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 50 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 16%
Student > Master 6 12%
Student > Ph. D. Student 5 10%
Student > Doctoral Student 3 6%
Student > Bachelor 3 6%
Other 3 6%
Unknown 22 44%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 9 18%
Neuroscience 8 16%
Pharmacology, Toxicology and Pharmaceutical Science 2 4%
Nursing and Health Professions 2 4%
Agricultural and Biological Sciences 2 4%
Other 4 8%
Unknown 23 46%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 September 2018.
All research outputs
#20,490,417
of 23,053,169 outputs
Outputs from Current topics in microbiology and immunology
#601
of 681 outputs
Outputs of similar age
#356,394
of 421,456 outputs
Outputs of similar age from Current topics in microbiology and immunology
#39
of 44 outputs
Altmetric has tracked 23,053,169 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 681 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.9. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 421,456 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 44 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.

This page is provided by Altmetric.