Chapter title |
The Unfolded Protein Response in the Immune Cell Development: Putting the Caretaker in the Driving Seat
|
---|---|
Chapter number | 1 |
Book title |
Coordinating Organismal Physiology Through the Unfolded Protein Response
|
Published in |
Current topics in microbiology and immunology, January 2017
|
DOI | 10.1007/82_2017_1 |
Pubmed ID | |
Book ISBNs |
978-3-31-978529-5, 978-3-31-978530-1
|
Authors |
Simon J. Tavernier, Bart N. Lambrecht, Sophie Janssens, Tavernier, Simon J., Lambrecht, Bart N., Janssens, Sophie |
Abstract |
The endoplasmic reticulum (ER) is the primary site for the folding of proteins destined for the membranous compartment and the extracellular space. This elaborate function is coordinated by the unfolded protein response (UPR), a stress-activated cellular program that governs proteostasis. In multicellular organisms, cells have adopted specialized functions, which required functional adaptations of the ER and its UPR. Recently, it has become clear that in immune cells, the UPR has acquired functions that stretch far beyond its original scope. In this review, we will discuss the role of the UPR in the immune system and highlight the plasticity of this signaling cascade throughout immune cell development . |
X Demographics
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 18 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 7 | 39% |
Student > Ph. D. Student | 3 | 17% |
Researcher | 3 | 17% |
Student > Doctoral Student | 1 | 6% |
Other | 1 | 6% |
Other | 1 | 6% |
Unknown | 2 | 11% |
Readers by discipline | Count | As % |
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Immunology and Microbiology | 4 | 22% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 17% |
Agricultural and Biological Sciences | 3 | 17% |
Biochemistry, Genetics and Molecular Biology | 3 | 17% |
Medicine and Dentistry | 2 | 11% |
Other | 1 | 6% |
Unknown | 2 | 11% |