Chapter title |
ER Protein Quality Control and the Unfolded Protein Response in the Heart
|
---|---|
Chapter number | 54 |
Book title |
Coordinating Organismal Physiology Through the Unfolded Protein Response
|
Published in |
Current topics in microbiology and immunology, January 2017
|
DOI | 10.1007/82_2017_54 |
Pubmed ID | |
Book ISBNs |
978-3-31-978529-5, 978-3-31-978530-1
|
Authors |
A. Arrieta, E. A. Blackwood, C. C. Glembotski |
Abstract |
Cardiac myocytes are the cells responsible for the robust ability of the heart to pump blood throughout the circulatory system. Cardiac myocytes grow in response to a variety of physiological and pathological conditions; this growth challenges endoplasmic reticulum-protein quality control (ER-PQC), a major feature of which includes the unfolded protein response (UPR). ER-PQC and the UPR in cardiac myocytes growing under physiological conditions, including normal development, exercise, and pregnancy, are sufficient to support hypertrophic growth of each cardiac myocyte. However, the ER-PQC and UPR are insufficient to respond to the challenge of cardiac myocyte growth under pathological conditions, including myocardial infarction and heart failure. In part, this insufficiency is due to a continual decline in the expression levels of important adaptive UPR components as a function of age and during myocardial pathology. This chapter will discuss the physiological and pathological conditions unique to the heart that involves ER-PQC, and whether the UPR is adaptive or maladaptive under these circumstances. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 26 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 5 | 19% |
Student > Master | 4 | 15% |
Researcher | 3 | 12% |
Student > Ph. D. Student | 3 | 12% |
Student > Doctoral Student | 2 | 8% |
Other | 4 | 15% |
Unknown | 5 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 10 | 38% |
Agricultural and Biological Sciences | 3 | 12% |
Medicine and Dentistry | 2 | 8% |
Immunology and Microbiology | 1 | 4% |
Sports and Recreations | 1 | 4% |
Other | 1 | 4% |
Unknown | 8 | 31% |