Chapter title |
Cell Non-autonomous UPRER Signaling
|
---|---|
Chapter number | 38 |
Book title |
Coordinating Organismal Physiology Through the Unfolded Protein Response
|
Published in |
Current topics in microbiology and immunology, January 2017
|
DOI | 10.1007/82_2017_38 |
Pubmed ID | |
Book ISBNs |
978-3-31-978529-5, 978-3-31-978530-1
|
Authors |
Soudabeh Imanikia, Ming Sheng, Rebecca C. Taylor, Imanikia, Soudabeh, Sheng, Ming, Taylor, Rebecca C. |
Abstract |
The UPR(ER) is an important regulator of secretory pathway homeostasis, and plays roles in many physiological processes. Its broad range of targets and ability to modulate secretion and membrane trafficking make it perfectly positioned to influence intercellular communication, enabling the UPR(ER) to coordinate physiological processes between cells and tissues. Recent evidence suggests that the activation of the UPR(ER) can itself be communicated between cells. This cell non-autonomous route to UPR(ER) activation occurs in multiple species, and enables organism-wide responses to stress that involve processes as diverse as immunity, metabolism, aging and reproduction. It may also play roles in disease progression, making the pathways that mediate cell non-autonomous UPR(ER) signaling a potential source of novel future therapeutics. |
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United Kingdom | 2 | 29% |
Unknown | 5 | 71% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 57% |
Scientists | 3 | 43% |
Mendeley readers
Geographical breakdown
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Unknown | 10 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 4 | 40% |
Student > Doctoral Student | 2 | 20% |
Student > Ph. D. Student | 1 | 10% |
Unknown | 3 | 30% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 4 | 40% |
Computer Science | 1 | 10% |
Neuroscience | 1 | 10% |
Chemistry | 1 | 10% |
Unknown | 3 | 30% |