Chapter title |
Gene Therapy for the Treatment of Neurological Disorders: Amyotrophic Lateral Sclerosis.
|
---|---|
Chapter number | 28 |
Book title |
Gene Therapy for Neurological Disorders
|
Published in |
Methods in molecular biology, January 2016
|
DOI | 10.1007/978-1-4939-3271-9_28 |
Pubmed ID | |
Book ISBNs |
978-1-4939-3270-2, 978-1-4939-3271-9
|
Authors |
McEachin, Zachary T, Donsante, Anthony, Boulis, Nicholas, Zachary T. McEachin, Anthony Donsante, Nicholas Boulis, McEachin, Zachary T. |
Abstract |
Gene therapy is a powerful tool for treating diseases, including neurological disorder such at amyotrophic lateral sclerosis. When delivered to the CNS, gene therapy vectors can provide prosurvival signals to neurons, knock down the expression of toxic proteins, or restore lost function. How to best deliver this type of therapeutic depends on the nature of the disease and the expected function of the transgene. Here we describe a method for parenchymal injection into rodent models, allowing for localized delivery of gene therapy vectors and other therapeutic molecules. This technique has been a robust mechanism for proof-of-principle experiments. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 19 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 6 | 32% |
Student > Master | 4 | 21% |
Student > Doctoral Student | 3 | 16% |
Student > Ph. D. Student | 2 | 11% |
Professor | 1 | 5% |
Other | 2 | 11% |
Unknown | 1 | 5% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 6 | 32% |
Biochemistry, Genetics and Molecular Biology | 4 | 21% |
Agricultural and Biological Sciences | 4 | 21% |
Nursing and Health Professions | 1 | 5% |
Psychology | 1 | 5% |
Other | 1 | 5% |
Unknown | 2 | 11% |