Chapter title |
Gene Therapy for the Treatment of Neurological Disorders: Central Nervous System Neoplasms
|
---|---|
Chapter number | 31 |
Book title |
Gene Therapy for Neurological Disorders
|
Published in |
Methods in molecular biology, January 2016
|
DOI | 10.1007/978-1-4939-3271-9_31 |
Pubmed ID | |
Book ISBNs |
978-1-4939-3270-2, 978-1-4939-3271-9
|
Authors |
Neha Kamran, Marianela Candolfi, Gregory J. Baker, Mariela Moreno Ayala, Marta Dzaman, Pedro R. Lowenstein, Maria G. Castro, Kamran, Neha, Candolfi, Marianela, Baker, Gregory J., Ayala, Mariela Moreno, Dzaman, Marta, Lowenstein, Pedro R., Castro, Maria G. |
Abstract |
Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults with a median survival of 16.2-21.2 months post diagnosis (Stupp et al., N Engl J Med 352(10): 987-996, 2005). Because of its location, complete surgical resection is impossible; additionally because GBM is also resistant to chemotherapeutic and radiotherapy approaches, development of novel therapies is urgently needed. In this chapter we describe the development of preclinical animal models and a conditionally cytotoxic and immune-stimulatory gene therapy strategy that successfully causes tumor regression in several rodent GBM models. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 19 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 6 | 32% |
Student > Bachelor | 4 | 21% |
Student > Doctoral Student | 2 | 11% |
Professor | 1 | 5% |
Professor > Associate Professor | 1 | 5% |
Other | 0 | 0% |
Unknown | 5 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 3 | 16% |
Neuroscience | 3 | 16% |
Agricultural and Biological Sciences | 2 | 11% |
Biochemistry, Genetics and Molecular Biology | 1 | 5% |
Computer Science | 1 | 5% |
Other | 3 | 16% |
Unknown | 6 | 32% |