Table of Contents

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   Book Overview
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   Chapter 1 Sidney Riegelman — The Wisconsin Years
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   Chapter 2 Sidney Riegelman — Friend and Colleague
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   Chapter 3 Sidney Riegelman — The Educator
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   Chapter 4 Sidney Riegelman — The Scientist
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   Chapter 5 Sidney Riegelman — His Contributions to Public Policy in Pharmacy and The Pharmaceutical Sciences
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   Chapter 6 Sidney Riegelman — Contributions at the Clinical Interface
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   Chapter 7 Personal Experiences in the Early Days of Biopharmacy and Pharmacokinetics
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   Chapter 8 Modern Pharmaceutical Dosage Forms
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    Chapter 9 Specificity of Esterases and Effect of Structure of Prodrug Esters of Acylated Acetaminophen on Hydrolytic Reactivity
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    Chapter 10 Transdermal Absorption: A Unique Opportunity for Drug Delivery
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    Chapter 11 Pharmacokinetics and Pharmaceutical Technology
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    Chapter 12 Bioavailability and Pharmacokinetics in Drug Development
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    Chapter 13 Clearance — Models, Validation and Implications
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    Chapter 14 Estimation of an Effective Half-Life
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    Chapter 15 Pharmacokinetic Aspects of Nonlinear Drug-Protein Binding
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    Chapter 16 Unusual Pharmacokinetics
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    Chapter 17 Assessment and Prediction of In Vivo Oxidative Drug Metabolizing Activity
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    Chapter 18 Pharmacokinetic and Pharmacological Aspects of Polymorphic Drug Oxidation in Man
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    Chapter 19 Problems in Correlating In Vitro and In Vivo Studies of Drug Metabolism
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    Chapter 20 Integral Procedures in Pharmacokinetics and their Application to the Parameter Determination of Appearing Metabolites
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    Chapter 21 Pharmacokinetics at the Interface Between Pharmacology and Physiology
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    Chapter 22 Methods for Drug Dosage Individualization: Past, Present and Future
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    Chapter 23 Treatment of Depression — Pharmacokinetic and Pharmacogenetic Considerations
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    Chapter 24 Kinetics of Drug Action
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    Chapter 25 Cancer Drug Delivery Systems: Macromolecular Prodrugs of Mitomycin C
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    Chapter 26 Organ Variation in Tissue to Plasma Partition Coefficients of Adriamycin, Daunomycin and Actinomycin-D: Correlation to Tissue DNA Concentrations
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    Chapter 27 Clinical Pharmacokinetics in the Therapeutic Management of Cancer Patients with Methotrexate and Adriamycin
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    Chapter 28 The Immunopharmacokinetics of Prednisone/Prednisolone
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    Chapter 29 The Interpretation of In Vivo Mean Dissolution Time Data
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    Chapter 30 Application of Statistical Moment Analysis to the Evaluation of Controlled Release Formulations
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    Chapter 31 Concept of Time-Averaged Total Clearance and Mean Residence Time in Michaelis-Menten Elimination Systems
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    Chapter 32 A General Method of Optimizing Individual Drug Dosage
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    Chapter 33 Estimation of Population Pharmacokinetic Parameters with the Computer System Nonmem: Patients Treated with Lidocaine and Mexiletine
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    Chapter 34 Considerations of Linear Regression with Errors in both Variables as Applied to Clinical Pharmacokinetics
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    Chapter 35 Intestinal Drug Metabolism — Presystemic and Systemic Mechanisms and Implications
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    Chapter 36 Pharmacokinetics of Aspirin: Total and Presystemic Clearance by Rats and Hydrolysis in Blood of Rats and Humans
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    Chapter 37 Do Plasma Concentrations of Acetaminophen and its Conjugated Metabolites Reflect Concentrations in Various Tissues?
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    Chapter 38 Interspecies Variations in Pharmacokinetics: A Perspective
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    Chapter 39 Nonrenal Elimination, Extensive Renal Tubular Reabsorption and Secretion of Creatinine in Humans and Animals
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    Chapter 40 Phenobarbital Pharmacokinetics with Particular Emphasis on the Treatment of Overdosed Patients
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    Chapter 41 Renal Elimination in Alcoholic Cirrhosis
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    Chapter 42 Altered Disposition of Naproxen by Cirrhotic and by Elderly Individuals
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    Chapter 43 Drug-Drug Interactions: Protean Manifestations
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    Chapter 44 Kinetics and Antiarrhythmic Effect of Dihydroquinidine
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    Chapter 45 Quinidine-N-Oxide: Structure and Pharmacokinetics of a New Quinidine Metabolite
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    Chapter 46 Phenobarbital Induction of Quinidine Plasma Protein Binding in Dogs and its Effect on Quinidine Disposition
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    Chapter 47 Covalent Binding of Quinidine
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    Chapter 48 The Use of the Portacaval Transposition Technique to Study Gastrointestinal and Hepatic Metabolism of Propranolol in Dogs
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    Chapter 49 Stereoselective Disposition and Glucuronidation of Propranolol in Man
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    Chapter 50 Effect of Renal and Hepatic Insufficiency on the Pharmacokinetics of Betaxolol, A New Adrenergic ß-Blocker
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    Chapter 51 A Selective HPLC Assay for Simultaneous Quantitation of Fourteen Methylxanthines and Methyluric Acids in Urine
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    Chapter 52 A Composite View of Theophylline Elimination in Man
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    Chapter 53 The Influence of Food on the Bioavailability of a Sustained Release Theophylline Formulation
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    Chapter 54 Pharmacokinetics of the Vasodilators Hydralazine and Endralazine
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    Chapter 55 Formation of Mono- and Dinitrate Metabolites of Nitroglycerin Following Incubation with Human Blood
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    Chapter 56 A Pharmacodynamic Model for Thiazinamium in Asthmatic Patients
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    Chapter 57 Protein Binding Estimates in the Presence of Volume Shifts During Equilibrium Dialysis
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    Chapter 58 Opiate Pharmacokinetics: In Vivo Receptor Binding and Pharmacological Effects
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    Chapter 59 Cefoperazone Pharmacokinetics in Healthy Chinese Volunteers