Chapter title |
Posttranslational Modifications of TGF-β Receptors.
|
---|---|
Chapter number | 3 |
Book title |
TGF-β Signaling
|
Published in |
Methods in molecular biology, January 2016
|
DOI | 10.1007/978-1-4939-2966-5_3 |
Pubmed ID | |
Book ISBNs |
978-1-4939-2965-8, 978-1-4939-2966-5
|
Authors |
Yan, Xiaohua, Chen, Ye-Guang, Xiaohua Yan, Ye-Guang Chen |
Abstract |
TGF-β is a prototype of the TGF-β cytokine superfamily and exerts multiple regulatory effects on cell activities. It signals through two types of membrane-bound serine/threonine kinase receptors. Upon TGF-β binding, the type II receptor TβRII recruits the type I receptor TβRI and form a functional heterocomplex. TβRII trans-phosphorylates the GS region of TβRI, thus triggering its kinase activity. Activated TβRI proceeds to activate downstream Smad2/3. Signal intensity and duration through the availability, activity and destiny of TGF-β receptors are finely controlled by multiple posttranslational modifications such as phosphorylation, ubiquitination, and neddylation. This chapter introduces methods for examination of these modifications of TGF-β receptors. |
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