Chapter title |
The Role of Ubiquitination to Determine Non-Smad Signaling Responses
|
---|---|
Chapter number | 23 |
Book title |
TGF-β Signaling
|
Published in |
Methods in molecular biology, January 2016
|
DOI | 10.1007/978-1-4939-2966-5_23 |
Pubmed ID | |
Book ISBNs |
978-1-4939-2965-8, 978-1-4939-2966-5
|
Authors |
Shyam Kumar Gudey, Marene Landström, Gudey, Shyam Kumar, Landström, Marene |
Abstract |
Ubiquitination is a posttranslational modification of proteins which acts as a key regulator of their function as well as fate. We have recently reported transforming growth factor β (TGFβ)-induced activation of non-Smad signaling responses through a specific Lys63-linked polyubiquitination of TGFβ type I receptor and TGFβ-associated kinase 1 (TAK1) that are utilized to specify cellular responses in cancer cells. This chapter gives a brief introduction of the biological importance of ubiquitination of proteins, the methods we have used for detecting new partners in the TGFβ signaling pathway and for performing ubiquitination assays. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Professor | 1 | 50% |
Lecturer > Senior Lecturer | 1 | 50% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 2 | 100% |