Chapter title |
Methods of myofibrillogenesis modeling.
|
---|---|
Chapter number | 6 |
Book title |
Cardiomyocytes
|
Published in |
Methods in molecular biology, January 2015
|
DOI | 10.1007/978-1-4939-2572-8_6 |
Pubmed ID | |
Book ISBNs |
978-1-4939-2571-1, 978-1-4939-2572-8
|
Authors |
Drew, Nancy K, Grosberg, Anna, Nancy K. Drew, Anna Grosberg, Drew, Nancy K. |
Abstract |
Organization in the heart is important on multiple length scales. Myofibrillogenesis processes control the assembly of this multi-scale architecture. Understanding myofibrillogenesis might allow us to better control self-assembly of cardiac tissues. One approach consists of creating phenomenological models and comparing these models to in vitro data from primary myocytes. In this chapter, we present a method for building these models to recapitulate different aspects of myofibrillogenesis. We present a specific example for a cardiomyocyte model, but the same procedure can be used to model fibrillogenesis with other mechanisms such as motility. In sum, the models allow for a better understanding of mechanisms behind self-assembly. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 6 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 2 | 33% |
Unspecified | 1 | 17% |
Researcher | 1 | 17% |
Student > Doctoral Student | 1 | 17% |
Unknown | 1 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Unspecified | 1 | 17% |
Biochemistry, Genetics and Molecular Biology | 1 | 17% |
Agricultural and Biological Sciences | 1 | 17% |
Engineering | 1 | 17% |
Unknown | 2 | 33% |