| Chapter title |
Identification and Analysis of Antiviral Compounds Against Poliovirus
|
|---|---|
| Chapter number | 17 |
| Book title |
Poliovirus
|
| Published in |
Methods in molecular biology, January 2016
|
| DOI | 10.1007/978-1-4939-3292-4_17 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-3291-7, 978-1-4939-3292-4
|
| Authors |
Pieter Leyssen, David Franco, Aloys Tijsma, Céline Lacroix, Armando De Palma, Johan Neyts, Leyssen, Pieter, Franco, David, Tijsma, Aloys, Lacroix, Céline, Palma, Armando De, Neyts, Johan |
| Abstract |
The Global Polio Eradication Initiative, launched in 1988, had as its goal the eradication of polio worldwide by the year 2000 through large-scale vaccinations campaigns with the live attenuated oral PV vaccine (OPV) (Griffiths et al., Biologicals 34:73-74, 2006). Despite substantial progress, polio remains endemic in several countries and new imported cases are reported on a regular basis ( http://www.polioeradication.org/casecount.asp ).It was recognized by the poliovirus research community that developing antivirals against poliovirus would be invaluable in the post-OPV era. Here, we describe three methods essential for the identification of selective inhibitors of poliovirus replication and for determining their mode of action by time-of-drug-addition studies as well as by the isolation of compound-resistant poliovirus variants. |
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|---|---|---|
| Unknown | 6 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 2 | 33% |
| Librarian | 1 | 17% |
| Researcher | 1 | 17% |
| Student > Master | 1 | 17% |
| Unknown | 1 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
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| Immunology and Microbiology | 1 | 17% |
| Social Sciences | 1 | 17% |
| Medicine and Dentistry | 1 | 17% |
| Other | 0 | 0% |
| Unknown | 1 | 17% |