Chapter title |
Hoffa’s Fat Pad Abnormality in the Development of Knee Osteoarthritis
|
---|---|
Chapter number | 77 |
Book title |
Current Concepts in Medical Research and Practice
|
Published in |
Advances in experimental medicine and biology, January 2017
|
DOI | 10.1007/5584_2017_77 |
Pubmed ID | |
Book ISBNs |
978-3-31-974149-9, 978-3-31-974150-5
|
Authors |
Wojciech Paduszyński, Mateusz Jeśkiewicz, Paweł Uchański, Sebastian Gackowski, Marek Radkowski, Urszula Demkow, Paduszyński, Wojciech, Jeśkiewicz, Mateusz, Uchański, Paweł, Gackowski, Sebastian, Radkowski, Marek, Demkow, Urszula |
Abstract |
Over the past two decades, many hypotheses have been put forward to explain the cause of knee osteoarthritis. Scientific reports bring up the role of adipose tissue in the activation of the inflammatory mechanisms, which is a characteristic feature of osteoarthritis natural history. Adipose tissue produces and releases cytokines, interleukins, and growth factors by means of paracrine, endocrine, and autocrine mechanisms. Hoffa's fat pad (infrapatellar adipose tissue) plays a viable role in the initiation and progression of osteoarthritis due to its role in the activation and release of pro-inflammatory mediators. The degenerative joint disease is considered an inflammatory process. Therefore, in this article we overview the importance of Hoffa's fat pad in the development and progression of osteoarthritis. |
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