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Mechanisms of Lymphocyte Activation and Immune Regulation VI

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Cover of 'Mechanisms of Lymphocyte Activation and Immune Regulation VI'

Table of Contents

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    Book Overview
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    Chapter 1 Apoptosis/Programmed Cell Death
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    Chapter 2 Apoptosis and Its Regulation
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    Chapter 3 Mechanisms for Recognition and Phagocytosis of Apoptotic Lymphocytes by Macrophages
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    Chapter 4 Cytotoxic Lymphocyte Killing Enters the Ice Age
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    Chapter 5 Cross-talk between ceramide and PKC activity in the control of apoptosis in WEHI-231.
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    Chapter 6 Cell Cycle Control of T Cell Apoptosis Induced by Activation Through the T Cell Antigen Receptor
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    Chapter 7 Role of antibody signaling in inducing tumor dormancy.
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    Chapter 8 Regulation of lymphoid apoptosis by Bcl-2 and Bcl-XL.
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    Chapter 9 The Epstein-Barr virus gene BHRF1, a homologue of the cellular oncogene Bcl-2, inhibits apoptosis induced by gamma radiation and chemotherapeutic drugs.
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    Chapter 10 Structure—Function Analysis of Bcl-2 Family Proteins
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    Chapter 11 Role of Ice-Proteases in Apoptosis
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    Chapter 12 Fas-mediated apoptosis.
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    Chapter 13 Fas Splicing Variants and their Effect on Apoptosis
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    Chapter 14 The Role of FasL and TNF in the Homeostatic Regulation of Immune Responses
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    Chapter 15 Signals for survival and apoptosis in normal and neoplastic B lymphocytes.
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    Chapter 16 Regulation of B Cell Apoptosis
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    Chapter 17 Apoptotic Cell Death in the Chicken Bursa of Fabricius
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    Chapter 18 Generation and Regulation of B Cell Autoreactivity Arising in the Periphery
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    Chapter 19 Inducible Resistance to Fas-Mediated Apoptosis in Primary B Lymphocytes
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    Chapter 20 The thymus and T cell death.
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    Chapter 21 Genetic Regulation of Apoptosis in the Mouse Thymus
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    Chapter 22 Regulation of T Cell Activation by CD28 and CTLA4
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    Chapter 23 Granzyme B-Induced Apoptosis
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    Chapter 24 Mature T Lymphocyte Apoptosis in the Healthy and Diseased Immune System
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    Chapter 25 Autoimmunity Due to Defective NUR77, Fas, and TNF-RI Apoptosis
Attention for Chapter 15: Signals for survival and apoptosis in normal and neoplastic B lymphocytes.
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Chapter title
Signals for survival and apoptosis in normal and neoplastic B lymphocytes.
Chapter number 15
Book title
Mechanisms of Lymphocyte Activation and Immune Regulation VI
Published in
Advances in experimental medicine and biology, January 1996
DOI 10.1007/978-1-4899-0274-0_15
Pubmed ID
Book ISBNs
978-1-4899-0276-4, 978-1-4899-0274-0
Authors

Gordon, J, Gregory, C D, Grafton, G, Pound, J D, Gordon, John, Gregory, Christopher D., Grafton, Gillian, Pound, John D.

Abstract

B lymphocytes are subject to selection within germinal centers following somatic hyper-mutation on immunoglobulin variable region genes based on their ability to bind antigen with high affinity. Non-selected cells die by apoptosis. Tumors with features of germinal center B cells include follicular center cell lymphoma and Burkitt's lymphoma. We have used the latter extensively as a neoplastic model of germinal center cells and have compared directly the behaviour of cell lines derived from biopsy material with that of the normal counterparts. Here we describe some of our findings in the two systems with regard to signals regulating survival and apoptosis.

Mendeley readers

The data shown below were compiled from readership statistics for 7 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 7 100%

Demographic breakdown

Readers by professional status Count As %
Professor 1 14%
Researcher 1 14%
Unknown 5 71%
Readers by discipline Count As %
Medicine and Dentistry 1 14%
Unknown 6 86%