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Mechanisms of Lymphocyte Activation and Immune Regulation VI

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Cover of 'Mechanisms of Lymphocyte Activation and Immune Regulation VI'

Table of Contents

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    Book Overview
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    Chapter 1 Apoptosis/Programmed Cell Death
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    Chapter 2 Apoptosis and Its Regulation
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    Chapter 3 Mechanisms for Recognition and Phagocytosis of Apoptotic Lymphocytes by Macrophages
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    Chapter 4 Cytotoxic Lymphocyte Killing Enters the Ice Age
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    Chapter 5 Cross-talk between ceramide and PKC activity in the control of apoptosis in WEHI-231.
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    Chapter 6 Cell Cycle Control of T Cell Apoptosis Induced by Activation Through the T Cell Antigen Receptor
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    Chapter 7 Role of antibody signaling in inducing tumor dormancy.
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    Chapter 8 Regulation of lymphoid apoptosis by Bcl-2 and Bcl-XL.
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    Chapter 9 The Epstein-Barr virus gene BHRF1, a homologue of the cellular oncogene Bcl-2, inhibits apoptosis induced by gamma radiation and chemotherapeutic drugs.
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    Chapter 10 Structure—Function Analysis of Bcl-2 Family Proteins
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    Chapter 11 Role of Ice-Proteases in Apoptosis
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    Chapter 12 Fas-mediated apoptosis.
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    Chapter 13 Fas Splicing Variants and their Effect on Apoptosis
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    Chapter 14 The Role of FasL and TNF in the Homeostatic Regulation of Immune Responses
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    Chapter 15 Signals for survival and apoptosis in normal and neoplastic B lymphocytes.
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    Chapter 16 Regulation of B Cell Apoptosis
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    Chapter 17 Apoptotic Cell Death in the Chicken Bursa of Fabricius
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    Chapter 18 Generation and Regulation of B Cell Autoreactivity Arising in the Periphery
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    Chapter 19 Inducible Resistance to Fas-Mediated Apoptosis in Primary B Lymphocytes
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    Chapter 20 The thymus and T cell death.
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    Chapter 21 Genetic Regulation of Apoptosis in the Mouse Thymus
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    Chapter 22 Regulation of T Cell Activation by CD28 and CTLA4
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    Chapter 23 Granzyme B-Induced Apoptosis
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    Chapter 24 Mature T Lymphocyte Apoptosis in the Healthy and Diseased Immune System
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    Chapter 25 Autoimmunity Due to Defective NUR77, Fas, and TNF-RI Apoptosis
Attention for Chapter 12: Fas-mediated apoptosis.
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Chapter title
Fas-mediated apoptosis.
Chapter number 12
Book title
Mechanisms of Lymphocyte Activation and Immune Regulation VI
Published in
Advances in experimental medicine and biology, January 1996
DOI 10.1007/978-1-4899-0274-0_12
Pubmed ID
Book ISBNs
978-1-4899-0276-4, 978-1-4899-0274-0

Shigekazu Nagata, Nagata, Shigekazu


Homeostasis in vertebrates is tightly regulated by cell death as well as by cell proliferation. The death of cells during embryogenesis, metamorphosis, endocrine-dependent tissue atrophy, and normal tissue turnover is "programmed cell death", mediated by a process called "apoptosis". Cytotoxic T lymphocytes and natural killer cells kill the target cells by inducing apoptosis. Apoptosis can be distinguished from necrosis, which occurs as a result of injury, complement attack, severe hypoxia and hyperthermia. Morphological and biochemical analyses of the apoptotic cell death process indicated that apoptosis is accompanied by condensation of cytoplasm, loss of plasma membrane microvilli, segmentation of nucleus, and extensive degradation of chromosomal DNA into oligomers of 180 bp. Cellular proliferation and differentiation are mediated by a family of proteins called cytokines. Our studies on the Fas ligand and Fas have indicated that apoptosis is also mediated by a cytokine and its receptor in some cases. Here, I summarize the current status of the Fas death factor system.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 3%
Egypt 1 3%
Unknown 33 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 26%
Student > Bachelor 8 23%
Student > Master 8 23%
Student > Doctoral Student 4 11%
Professor 1 3%
Other 1 3%
Unknown 4 11%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 11 31%
Agricultural and Biological Sciences 9 26%
Immunology and Microbiology 4 11%
Medicine and Dentistry 3 9%
Veterinary Science and Veterinary Medicine 2 6%
Other 2 6%
Unknown 4 11%