↓ Skip to main content

Mechanisms of Lymphocyte Activation and Immune Regulation VI

Overview of attention for book
Cover of 'Mechanisms of Lymphocyte Activation and Immune Regulation VI'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 Apoptosis/Programmed Cell Death
  3. Altmetric Badge
    Chapter 2 Apoptosis and Its Regulation
  4. Altmetric Badge
    Chapter 3 Mechanisms for Recognition and Phagocytosis of Apoptotic Lymphocytes by Macrophages
  5. Altmetric Badge
    Chapter 4 Cytotoxic Lymphocyte Killing Enters the Ice Age
  6. Altmetric Badge
    Chapter 5 Cross-talk between ceramide and PKC activity in the control of apoptosis in WEHI-231.
  7. Altmetric Badge
    Chapter 6 Cell Cycle Control of T Cell Apoptosis Induced by Activation Through the T Cell Antigen Receptor
  8. Altmetric Badge
    Chapter 7 Role of antibody signaling in inducing tumor dormancy.
  9. Altmetric Badge
    Chapter 8 Regulation of lymphoid apoptosis by Bcl-2 and Bcl-XL.
  10. Altmetric Badge
    Chapter 9 The Epstein-Barr virus gene BHRF1, a homologue of the cellular oncogene Bcl-2, inhibits apoptosis induced by gamma radiation and chemotherapeutic drugs.
  11. Altmetric Badge
    Chapter 10 Structure—Function Analysis of Bcl-2 Family Proteins
  12. Altmetric Badge
    Chapter 11 Role of Ice-Proteases in Apoptosis
  13. Altmetric Badge
    Chapter 12 Fas-mediated apoptosis.
  14. Altmetric Badge
    Chapter 13 Fas Splicing Variants and their Effect on Apoptosis
  15. Altmetric Badge
    Chapter 14 The Role of FasL and TNF in the Homeostatic Regulation of Immune Responses
  16. Altmetric Badge
    Chapter 15 Signals for survival and apoptosis in normal and neoplastic B lymphocytes.
  17. Altmetric Badge
    Chapter 16 Regulation of B Cell Apoptosis
  18. Altmetric Badge
    Chapter 17 Apoptotic Cell Death in the Chicken Bursa of Fabricius
  19. Altmetric Badge
    Chapter 18 Generation and Regulation of B Cell Autoreactivity Arising in the Periphery
  20. Altmetric Badge
    Chapter 19 Inducible Resistance to Fas-Mediated Apoptosis in Primary B Lymphocytes
  21. Altmetric Badge
    Chapter 20 The thymus and T cell death.
  22. Altmetric Badge
    Chapter 21 Genetic Regulation of Apoptosis in the Mouse Thymus
  23. Altmetric Badge
    Chapter 22 Regulation of T Cell Activation by CD28 and CTLA4
  24. Altmetric Badge
    Chapter 23 Granzyme B-Induced Apoptosis
  25. Altmetric Badge
    Chapter 24 Mature T Lymphocyte Apoptosis in the Healthy and Diseased Immune System
  26. Altmetric Badge
    Chapter 25 Autoimmunity Due to Defective NUR77, Fas, and TNF-RI Apoptosis
Attention for Chapter 12: Fas-mediated apoptosis.
Altmetric Badge

Citations

dimensions_citation
5 Dimensions

Readers on

mendeley
31 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Chapter title
Fas-mediated apoptosis.
Chapter number 12
Book title
Mechanisms of Lymphocyte Activation and Immune Regulation VI
Published in
Advances in experimental medicine and biology, January 1996
DOI 10.1007/978-1-4899-0274-0_12
Pubmed ID
Book ISBNs
978-1-4899-0276-4, 978-1-4899-0274-0
Authors

Shigekazu Nagata, Nagata, Shigekazu

Abstract

Homeostasis in vertebrates is tightly regulated by cell death as well as by cell proliferation. The death of cells during embryogenesis, metamorphosis, endocrine-dependent tissue atrophy, and normal tissue turnover is "programmed cell death", mediated by a process called "apoptosis". Cytotoxic T lymphocytes and natural killer cells kill the target cells by inducing apoptosis. Apoptosis can be distinguished from necrosis, which occurs as a result of injury, complement attack, severe hypoxia and hyperthermia. Morphological and biochemical analyses of the apoptotic cell death process indicated that apoptosis is accompanied by condensation of cytoplasm, loss of plasma membrane microvilli, segmentation of nucleus, and extensive degradation of chromosomal DNA into oligomers of 180 bp. Cellular proliferation and differentiation are mediated by a family of proteins called cytokines. Our studies on the Fas ligand and Fas have indicated that apoptosis is also mediated by a cytokine and its receptor in some cases. Here, I summarize the current status of the Fas death factor system.

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 3%
Egypt 1 3%
Unknown 29 94%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 9 29%
Student > Master 7 23%
Student > Ph. D. Student 6 19%
Student > Doctoral Student 4 13%
Professor 1 3%
Other 1 3%
Unknown 3 10%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 10 32%
Agricultural and Biological Sciences 9 29%
Immunology and Microbiology 4 13%
Medicine and Dentistry 3 10%
Veterinary Science and Veterinary Medicine 1 3%
Other 1 3%
Unknown 3 10%