Chapter title |
Whole-Cell Biosensors as Tools for the Detection of Quorum-Sensing Molecules: Uses in Diagnostics and the Investigation of the Quorum-Sensing Mechanism.
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Chapter number | 337 |
Book title |
Bioluminescence: Fundamentals and Applications in Biotechnology - Volume 3
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Published in |
Advances in biochemical engineering biotechnology, October 2015
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DOI | 10.1007/10_2015_337 |
Pubmed ID | |
Book ISBNs |
978-3-31-927405-8, 978-3-31-927407-2
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Authors |
O'Connor, Gregory, Knecht, Leslie D, Salgado, Nelson, Strobel, Sebastian, Pasini, Patrizia, Daunert, Sylvia, Gregory O’Connor, Leslie D. Knecht, Nelson Salgado, Sebastian Strobel, Patrizia Pasini, Sylvia Daunert, O’Connor, Gregory, Knecht, Leslie D. |
Abstract |
Genetically engineered bacterial whole-cell biosensors are powerful tools that take advantage of bacterial proteins and pathways to allow for detection of a specific analyte. These biosensors have been employed for a broad range of applications, including the detection of bacterial quorum-sensing molecules (QSMs). Bacterial QSMs are the small molecules bacteria use for population density-dependent communication, a process referred to as quorum sensing (QS). Various research groups have investigated the presence of QSMs, including N-acyl homoserine lactones (AHLs) and autoinducer-2 (AI-2), in physiological samples in attempts to enhance our knowledge of the role of bacteria and QS in disease states. Continued studies in these fields may allow for improved patient care and therapeutics based upon QSMs. Furthermore, bacterial whole-cell biosensors have elucidated the roles of some antibiotics as QS agonists and antagonists. Graphical Abstract. |
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Librarian | 1 | 3% |
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