Chapter title |
Therapeutic Antibodies for Biodefense
|
---|---|
Chapter number | 9 |
Book title |
Recombinant Antibodies for Infectious Diseases
|
Published in |
Advances in experimental medicine and biology, January 2017
|
DOI | 10.1007/978-3-319-72077-7_9 |
Pubmed ID | |
Book ISBNs |
978-3-31-972076-0, 978-3-31-972077-7
|
Authors |
Avril, Arnaud |
Abstract |
Diseases can be caused naturally by biological agents such as bacteria, viruses and toxins (natural risk). However, such biological agents can be intentionally disseminated in the environment by a State (military context) or terrorists to cause diseases in a population or livestock, to destabilize a nation by creating a climate of terror, destabilizing the economy and undermining institutions. Biological agents can be classified according to the severity of illness they cause, its mortality and how easily the agent can be spread. The Centers for Diseases Control and Prevention (CDC) classify biological agents in three categories (A, B and C); Category A consists of the six pathogens most suitable for use as bioweapons (Bacillus anthracis, Yersinia pestis, Francisella tularensis, botulinum neurotoxins, smallpox and viral hemorrhagic fevers). Antibodies represent a perfect biomedical countermeasure as they present both prophylactic and therapeutic properties, act fast and are highly specific to the target. This review focuses on the main biological agents that could be used as bioweapons, the history of biowarfare and antibodies that have been developed to neutralize these agents. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 21 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 4 | 19% |
Student > Postgraduate | 2 | 10% |
Student > Bachelor | 2 | 10% |
Librarian | 1 | 5% |
Student > Doctoral Student | 1 | 5% |
Other | 2 | 10% |
Unknown | 9 | 43% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 3 | 14% |
Biochemistry, Genetics and Molecular Biology | 2 | 10% |
Agricultural and Biological Sciences | 2 | 10% |
Environmental Science | 1 | 5% |
Arts and Humanities | 1 | 5% |
Other | 3 | 14% |
Unknown | 9 | 43% |