Chapter title |
Serotonin, dieting, and bulimia nervosa.
|
---|---|
Chapter number | 14 |
Book title |
Tryptophan, Serotonin, and Melatonin
|
Published in |
Advances in experimental medicine and biology, January 1999
|
DOI | 10.1007/978-1-4615-4709-9_14 |
Pubmed ID | |
Book ISBNs |
978-1-4613-7133-5, 978-1-4615-4709-9
|
Authors |
Cowen, P J, Smith, K A, P. J. Cowen, K. A. Smith, Cowen, P. J., Smith, K. A. |
Abstract |
Dieting is a common behaviour which may trigger eating disorders such as bulimia nervosa in predisposed subjects. We found that in healthy women moderate dieting for 3 weeks lowered plasma concentrations of the 5-HT precursor, L-tryptophan (TRP) and impaired brain 5-HT neurotransmission as judged by 5-HT neuroendocrine tests. In recovered female subjects with a history of bulimia nervosa we found that TRP depletion produced by an amino acid mixture lacking TRP caused a temporary return of depressive symptoms together with concerns about weight and shape and fear of loss of control of eating. Taken together the data suggest that dieting-induced decreases in TRP availability may trigger the development of bulimia nervosa is susceptible individuals. |
X Demographics
Geographical breakdown
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 22 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 5 | 23% |
Student > Doctoral Student | 5 | 23% |
Student > Bachelor | 3 | 14% |
Researcher | 3 | 14% |
Professor | 2 | 9% |
Other | 5 | 23% |
Readers by discipline | Count | As % |
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Psychology | 8 | 36% |
Medicine and Dentistry | 4 | 18% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 5% |
Biochemistry, Genetics and Molecular Biology | 1 | 5% |
Social Sciences | 1 | 5% |
Other | 3 | 14% |
Unknown | 4 | 18% |