Chapter title |
The tryptophan depletion test. Impact on sleep in healthy subjects and patients with obsessive-compulsive disorder.
|
---|---|
Chapter number | 5 |
Book title |
Tryptophan, Serotonin, and Melatonin
|
Published in |
Advances in experimental medicine and biology, January 1999
|
DOI | 10.1007/978-1-4615-4709-9_5 |
Pubmed ID | |
Book ISBNs |
978-1-4613-7133-5, 978-1-4615-4709-9
|
Authors |
C Huwig-Poppe, U Voderholzer, J Backhaus, D Riemann, A König, F Hohagen, Ch. Huwig-Poppe, U. Voderholzer, J. Backhaus, D. Riemann, A. König, F. Hohagen, Huwig-Poppe, Ch., Voderholzer, U., Backhaus, J., Riemann, D., König, A., Hohagen, F. |
Abstract |
The tryptophan depletion test is a research tool to study the functional consequences of decreasing the brain serotonin metabolism. Since serotonin is involved in sleep regulation and assumed to be of high importance in the etiology of psychiatric disorders, the acute polysomnographic effects of tryptophan depletion were studied in healthy subjects and patients with obsessive compulsive disorder (OCD). According to the reciprocal interaction model of non-REM and REM-sleep regulation we expected that tryptophan depletion in healthy controls should provoke alterations of sleep similar to depression, whereas we assumed that these effects would be more pronounced in patients with OCD. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 3% |
Canada | 1 | 3% |
Unknown | 32 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 5 | 15% |
Student > Ph. D. Student | 5 | 15% |
Professor | 4 | 12% |
Other | 3 | 9% |
Researcher | 2 | 6% |
Other | 3 | 9% |
Unknown | 12 | 35% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 7 | 21% |
Psychology | 5 | 15% |
Neuroscience | 3 | 9% |
Engineering | 2 | 6% |
Agricultural and Biological Sciences | 1 | 3% |
Other | 1 | 3% |
Unknown | 15 | 44% |