Chapter title |
Tryptophan catabolism in synovial fluid of various arthropathies and its relationship with inflammatory cytokines.
|
---|---|
Chapter number | 70 |
Book title |
Tryptophan, Serotonin, and Melatonin
|
Published in |
Advances in experimental medicine and biology, January 1999
|
DOI | 10.1007/978-1-4615-4709-9_70 |
Pubmed ID | |
Book ISBNs |
978-1-4613-7133-5, 978-1-4615-4709-9
|
Authors |
Bertazzo, A, Punzi, L, Bertazzolo, N, Pianon, M, Pozzuoli, A, Costa, C V, Allegri, G, Antonella Bertazzo, Leonardo Punzi, Nidia Bertazzolo, Margherita Pianon, Assunta Pozzuoli, Carlo V. L. Costa, Graziella Allegri, Bertazzo, Antonella, Punzi, Leonardo, Bertazzolo, Nidia, Pianon, Margherita, Pozzuoli, Assunta, Costa, Carlo V. L., Allegri, Graziella |
Abstract |
Synovial fluids (SF) from patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA), gout, and osteoarthritis (OA) were investigated for the levels of interleukin (IL)-1 beta, IL-6 and IL-8, tryptophan (Trp) and indoleamine 2,3-dioxygenase (IDO) activity. Significant differences exist in the levels of IL-1 beta between inflammatory arthritides RA, PsA and gout and non inflammatory arthritis, such as OA. The highest concentration of IL-1 beta was found in RA, that showed high levels also of IL-6 and IL-8. In the same disease we also found the highest IDO activity and the lowest Trp concentration. In addition, IDO activity seems to be related with the decrease in Trp, as demonstrated by the inverse correlation found between these two substances in the SF of all patients. |
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