| Chapter title |
Peptide and Peptide Library Cyclization via Bromomethylbenzene Derivatives.
|
|---|---|
| Chapter number | 8 |
| Book title |
Peptide Libraries
|
| Published in |
Methods in molecular biology, January 2015
|
| DOI | 10.1007/978-1-4939-2020-4_8 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-2019-8, 978-1-4939-2020-4
|
| Authors |
Hacker DE, Almohaini M, Anbazhagan A, Ma Z, Hartman MC, David E. Hacker, Mohammed Almohaini, Aruna Anbazhagan, Zhong Ma, Matthew C. T. Hartman, Hacker, David E., Almohaini, Mohammed, Anbazhagan, Aruna, Ma, Zhong, Hartman, Matthew C. T. |
| Abstract |
Cyclization confers several advantages to peptides, cumulatively serving to make them more drug-like. In this protocol, cyclic peptides are generated via bis-alkylation of cysteine-containing peptides using α,α'-dibromo-m-xylene. The reactions are robust and high yielding. Multiple reaction platforms for the application of this versatile strategy are described herein: the cyclization of solid-phase-synthesized peptides, both in solution and on resin, as well as the cyclization of in vitro translated mRNA-peptide fusion libraries on oligo(dT) resin. |
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Mendeley readers
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| Student > Bachelor | 1 | 9% |
| Student > Doctoral Student | 1 | 9% |
| Professor | 1 | 9% |
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| Unknown | 2 | 18% |