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Neurodegeneration

Overview of attention for book
Cover of 'Neurodegeneration'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 Introduction to Neurodegenerative Diseases and Related Techniques
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    Chapter 2 In Vivo and In Vitro Determination of Cell Death Markers in Neurons
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    Chapter 3 Degenerating Processes Identified by Electron Microscopic Immunocytochemical Methods
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    Chapter 4 Isolation and Culture of Neurons and Astrocytes from the Mouse Brain Cortex
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    Chapter 5 Isolation and Culture of Postnatal Spinal Motoneurons
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    Chapter 6 Converting Human Pluripotent Stem Cells to Neural Tissue and Neurons to Model Neurodegeneration
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    Chapter 7 Neurodegeneration
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    Chapter 8 Developing yeast models of human neurodegenerative disorders.
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    Chapter 9 Modeling Dopamine Neuron Degeneration in Caenorhabditis elegans
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    Chapter 10 Role of the Proteasome in Fly Models of Neurodegeneration
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    Chapter 11 Neurodegeneration
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    Chapter 12 Practical Considerations of Genetic Rodent Models for Neurodegenerative Diseases
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    Chapter 13 Modeling Focal Cerebral Ischemia In Vivo
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    Chapter 14 Pharmacological Models of Parkinson’s Disease in Rodents
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    Chapter 15 Behavioral Phenotyping of Mouse Models of Neurodegeneration
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    Chapter 16 Characterization of Amyloid Deposits in Neurodegenerative Diseases
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    Chapter 17 Detection of Protein Aggregation in Neurodegenerative Diseases
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    Chapter 18 Assessment of Proteasome Impairment and Accumulation/Aggregation of Ubiquitinated Proteins in Neuronal Cultures
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    Chapter 19 Measurements of Threshold of Mitochondrial Permeability Transition Pore Opening in Intact and Permeabilized Cells by Flash Photolysis of Caged Calcium
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    Chapter 20 Isolation and Functional Assessment of Mitochondria from Small Amounts of Mouse Brain Tissue
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    Chapter 21 Monitoring Mitophagy in Neuronal Cell Cultures
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    Chapter 22 Analysis of Vesicular Trafficking in Primary Neurons by Live Imaging
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    Chapter 23 Surface Trafficking of Sodium Channels in Cells and in Hippocampal Slices
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    Chapter 24 Imaging Presynaptic Exocytosis in Corticostriatal Slices
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    Chapter 25 Microscopic Imaging of Intracellular Calcium in Live Cells Using Lifetime-Based Ratiometric Measurements of Oregon Green BAPTA-1
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    Chapter 26 Electrophysiological Characterization of Neuromuscular Synaptic Dysfunction in Mice
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    Chapter 27 Determination of Neurotransmitter Levels in Models of Parkinson’s Disease by HPLC-ECD
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    Chapter 28 Designing, Performing, and Interpreting a Microarray-Based Gene Expression Study
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    Chapter 29 Adeno-Associated Viral Gene Delivery in Neurodegenerative Disease
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    Chapter 30 Specific Gene Silencing Using RNAi in Cell Culture.
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    Chapter 31 Stem Cell Transplantation for Spinal Cord Neurodegeneration
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    Chapter 32 Evaluation of histone deacetylase inhibitors as therapeutics for neurodegenerative diseases.
  34. Altmetric Badge
    Chapter 33 Erratum to: Microscopic Imaging of Intracellular Calcium in Live Cells Using Lifetime-Based Ratiometric Measurements of Oregon Green BAPTA-1
  35. Altmetric Badge
    Chapter 34 Erratum to: Adeno-Associated Viral Gene Delivery in Neurodegenerative Disease
Attention for Chapter 8: Developing yeast models of human neurodegenerative disorders.
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Chapter title
Developing yeast models of human neurodegenerative disorders.
Chapter number 8
Book title
Neurodegeneration
Published in
Methods in molecular biology, September 2011
DOI 10.1007/978-1-61779-328-8_8
Pubmed ID
Book ISBNs
978-1-61779-327-1, 978-1-61779-328-8
Authors

Ocampo A, Barrientos A, Alejandro Ocampo, Antoni Barrientos, Ocampo, Alejandro, Barrientos, Antoni

Abstract

Neurodegenerative diseases represent one of the most devastating types of diseases in older populations in our time. Significant efforts have been made over the last 20 years to understand the molecular, biochemical, and physiological alterations underlying these diseases. However, in most cases, little is known about their pathological mechanisms due to their high complexity and involvement of a multiplicity of cellular pathways. To gain insight into this group of disorders and to devise potential therapeutic approaches, cellular and animal models of neurodegenerative proteinopathies have been created. Among them, the yeast Saccharomyces cerevisiae has been one of the most popular model organisms due to the degree of conservation of many biological pathways from yeast to human as well as its ease of use. Here, we describe how to create yeast models of neurodegenerative proteinopathies by ectopic expression of human proteins and how to perform a basic characterization of these models by analyzing cellular toxicity and protein aggregation.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 16 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 3 19%
Researcher 3 19%
Student > Ph. D. Student 3 19%
Student > Master 2 13%
Professor 1 6%
Other 1 6%
Unknown 3 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 4 25%
Biochemistry, Genetics and Molecular Biology 3 19%
Pharmacology, Toxicology and Pharmaceutical Science 1 6%
Computer Science 1 6%
Medicine and Dentistry 1 6%
Other 1 6%
Unknown 5 31%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 January 2012.
All research outputs
#17,118,920
of 21,200,018 outputs
Outputs from Methods in molecular biology
#6,903
of 11,952 outputs
Outputs of similar age
#198,521
of 252,501 outputs
Outputs of similar age from Methods in molecular biology
#342
of 510 outputs
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So far Altmetric has tracked 11,952 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 26th percentile – i.e., 26% of its peers scored the same or lower than it.
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We're also able to compare this research output to 510 others from the same source and published within six weeks on either side of this one. This one is in the 10th percentile – i.e., 10% of its contemporaries scored the same or lower than it.