Ocampo A, Barrientos A, Alejandro Ocampo, Antoni Barrientos, Ocampo, Alejandro, Barrientos, Antoni
Abstract
Neurodegenerative diseases represent one of the most devastating types of diseases in older populations in our time. Significant efforts have been made over the last 20 years to understand the molecular, biochemical, and physiological alterations underlying these diseases. However, in most cases, little is known about their pathological mechanisms due to their high complexity and involvement of a multiplicity of cellular pathways. To gain insight into this group of disorders and to devise potential therapeutic approaches, cellular and animal models of neurodegenerative proteinopathies have been created. Among them, the yeast Saccharomyces cerevisiae has been one of the most popular model organisms due to the degree of conservation of many biological pathways from yeast to human as well as its ease of use. Here, we describe how to create yeast models of neurodegenerative proteinopathies by ectopic expression of human proteins and how to perform a basic characterization of these models by analyzing cellular toxicity and protein aggregation.
Pharmacology, Toxicology and Pharmaceutical Science
1
6%
Computer Science
1
6%
Medicine and Dentistry
1
6%
Other
1
6%
Unknown
6
35%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 January 2012.
All research outputs
#18,303,566
of 22,661,413 outputs
Outputs from Methods in molecular biology
#7,810
of 13,020 outputs
Outputs of similar age
#104,955
of 126,331 outputs
Outputs of similar age from Methods in molecular biology
#24
of 37 outputs
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So far Altmetric has tracked 13,020 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
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