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Neurodegeneration

Overview of attention for book
Cover of 'Neurodegeneration'

Table of Contents

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    Book Overview
  2. Altmetric Badge
    Chapter 1 Introduction to Neurodegenerative Diseases and Related Techniques
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    Chapter 2 In Vivo and In Vitro Determination of Cell Death Markers in Neurons
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    Chapter 3 Degenerating Processes Identified by Electron Microscopic Immunocytochemical Methods
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    Chapter 4 Isolation and Culture of Neurons and Astrocytes from the Mouse Brain Cortex
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    Chapter 5 Isolation and Culture of Postnatal Spinal Motoneurons
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    Chapter 6 Converting Human Pluripotent Stem Cells to Neural Tissue and Neurons to Model Neurodegeneration
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    Chapter 7 Neurodegeneration
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    Chapter 8 Developing yeast models of human neurodegenerative disorders.
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    Chapter 9 Modeling Dopamine Neuron Degeneration in Caenorhabditis elegans
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    Chapter 10 Role of the Proteasome in Fly Models of Neurodegeneration
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    Chapter 11 Neurodegeneration
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    Chapter 12 Practical Considerations of Genetic Rodent Models for Neurodegenerative Diseases
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    Chapter 13 Modeling Focal Cerebral Ischemia In Vivo
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    Chapter 14 Pharmacological Models of Parkinson’s Disease in Rodents
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    Chapter 15 Behavioral Phenotyping of Mouse Models of Neurodegeneration
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    Chapter 16 Characterization of Amyloid Deposits in Neurodegenerative Diseases
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    Chapter 17 Detection of Protein Aggregation in Neurodegenerative Diseases
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    Chapter 18 Assessment of Proteasome Impairment and Accumulation/Aggregation of Ubiquitinated Proteins in Neuronal Cultures
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    Chapter 19 Measurements of Threshold of Mitochondrial Permeability Transition Pore Opening in Intact and Permeabilized Cells by Flash Photolysis of Caged Calcium
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    Chapter 20 Isolation and Functional Assessment of Mitochondria from Small Amounts of Mouse Brain Tissue
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    Chapter 21 Monitoring Mitophagy in Neuronal Cell Cultures
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    Chapter 22 Analysis of Vesicular Trafficking in Primary Neurons by Live Imaging
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    Chapter 23 Surface Trafficking of Sodium Channels in Cells and in Hippocampal Slices
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    Chapter 24 Imaging Presynaptic Exocytosis in Corticostriatal Slices
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    Chapter 25 Microscopic Imaging of Intracellular Calcium in Live Cells Using Lifetime-Based Ratiometric Measurements of Oregon Green BAPTA-1
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    Chapter 26 Electrophysiological Characterization of Neuromuscular Synaptic Dysfunction in Mice
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    Chapter 27 Determination of Neurotransmitter Levels in Models of Parkinson’s Disease by HPLC-ECD
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    Chapter 28 Designing, Performing, and Interpreting a Microarray-Based Gene Expression Study
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    Chapter 29 Adeno-Associated Viral Gene Delivery in Neurodegenerative Disease
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    Chapter 30 Specific Gene Silencing Using RNAi in Cell Culture.
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    Chapter 31 Stem Cell Transplantation for Spinal Cord Neurodegeneration
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    Chapter 32 Evaluation of histone deacetylase inhibitors as therapeutics for neurodegenerative diseases.
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    Chapter 33 Erratum to: Microscopic Imaging of Intracellular Calcium in Live Cells Using Lifetime-Based Ratiometric Measurements of Oregon Green BAPTA-1
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    Chapter 34 Erratum to: Adeno-Associated Viral Gene Delivery in Neurodegenerative Disease
Attention for Chapter 32: Evaluation of histone deacetylase inhibitors as therapeutics for neurodegenerative diseases.
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Chapter title
Evaluation of histone deacetylase inhibitors as therapeutics for neurodegenerative diseases.
Chapter number 32
Book title
Neurodegeneration
Published in
Methods in molecular biology, January 2011
DOI 10.1007/978-1-61779-328-8_32
Pubmed ID
Book ISBNs
978-1-61779-327-1, 978-1-61779-328-8
Authors

Elisabetta Soragni, Chunping Xu, Andrew Cooper, Heather L. Plasterer, James R. Rusche, Joel M. Gottesfeld, Soragni, Elisabetta, Xu, Chunping, Cooper, Andrew, Plasterer, Heather L., Rusche, James R., Gottesfeld, Joel M.

Abstract

Various neurodegenerative diseases are associated with aberrant gene expression. We recently identified a novel class of pimelic o-aminobenzamide histone deacetylase (HDAC) inhibitors that show promise as therapeutics in the neurodegenerative diseases Friedreich's ataxia (FRDA) and Huntington's disease (HD). Here, we describe the various techniques used in our laboratories to dissect mechanisms of gene silencing in FRDA and HD, and to test our HDAC inhibitors for their ability to reverse changes in gene expression in cellular models.

Mendeley readers

The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 3%
Unknown 37 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 32%
Unspecified 4 11%
Student > Bachelor 3 8%
Student > Postgraduate 3 8%
Professor > Associate Professor 3 8%
Other 8 21%
Unknown 5 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 9 24%
Biochemistry, Genetics and Molecular Biology 6 16%
Unspecified 4 11%
Neuroscience 4 11%
Chemistry 3 8%
Other 6 16%
Unknown 6 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 September 2011.
All research outputs
#20,145,561
of 22,651,245 outputs
Outputs from Methods in molecular biology
#9,791
of 13,012 outputs
Outputs of similar age
#169,773
of 180,239 outputs
Outputs of similar age from Methods in molecular biology
#198
of 229 outputs
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So far Altmetric has tracked 13,012 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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