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Mendeley readers
Chapter title |
Anti-neutrophil cytoplasm antibodies (ANCA) increase neutrophil adhesion to cultured human endothelium.
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Chapter number | 19 |
Book title |
ANCA-Associated Vasculitides
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Published in |
Advances in experimental medicine and biology, January 1993
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DOI | 10.1007/978-1-4757-9182-2_19 |
Pubmed ID | |
Book ISBNs |
978-1-4757-9184-6, 978-1-4757-9182-2
|
Authors |
M. T. Keogan, I. Rifkin, N. Ronda, C. M. Lockwood, D. L. Brown, Keogan, M. T., Rifkin, I., Ronda, N., Lockwood, C. M., Brown, D. L. |
Abstract |
ANCA have been demonstrated to activate normal neutrophils in vitro. This study demonstrates that ANCA positive IgG and Fab2 fragments increase the adhesion of normal neutrophils to cultured human umbilical vein endothelium (HUVEC), and that preincubation of the endothelial monolayers with tumour necrosis factor (TNF) to activate the endothelium enhances this effect. Preincubation of neutrophils with anti-CD18 monoclonal antibodies inhibited adhesion, suggesting that the observed effect was integrin mediated. |
Mendeley readers
The data shown below were compiled from readership statistics for 4 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 25% |
Unknown | 3 | 75% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 3 | 75% |
Professor | 1 | 25% |
Student > Doctoral Student | 1 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 2 | 50% |
Neuroscience | 1 | 25% |
Biochemistry, Genetics and Molecular Biology | 1 | 25% |