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Mendeley readers
Chapter title |
Pharmacologically directed design of leukemia therapy.
|
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Chapter number | 111 |
Book title |
Acute Leukemias II
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Published in |
Haematology and blood transfusion, January 1990
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DOI | 10.1007/978-3-642-74643-7_111 |
Pubmed ID | |
Book ISBNs |
978-3-54-050984-4, 978-3-64-274643-7
|
Authors |
Plunkett, W, Heinemann, V, Estey, E, Keating, M, Plunkett, W., Heinemann, V., Estey, E., Keating, M. |
Abstract |
The ability to accumulate and retain the active metabolite of Ara-C varies widely among patients. Our studies demonstrate a significant correlation between clinical response and the pharmacokinetics of Ara-CTP in leukemia cells during therapy. Knowledge of the cellular pharmacology of Ara-CTP has been used to optimize dose rates and to design combination treatment schedules. An understanding of the cellular pharmacodynamics of other drugs is likely to be a useful parameter for planning treatment protocols. |
Mendeley readers
The data shown below were compiled from readership statistics for 1 Mendeley reader of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 1 | 100% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 1 | 100% |