Chapter title |
Treatment of poor-prognosis, newly diagnosed acute myelogenous leukemia with high-dose cytosine arabinoside (Ara-C) and rHUGM-CSF.
|
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Chapter number | 134 |
Book title |
Acute Leukemias II
|
Published in |
Haematology and blood transfusion, January 1990
|
DOI | 10.1007/978-3-642-74643-7_134 |
Pubmed ID | |
Book ISBNs |
978-3-54-050984-4, 978-3-64-274643-7
|
Authors |
Estey, E H, Kantarjian, H M, Beran, M, McCredie, K B, Keating, M J, Deisseroth, A, Gutterman, J U, Estey, E. H., Kantarjian, H. M., Beran, M., McCredie, K. B., Keating, M. J., Deisseroth, A., Gutterman, J. U. |
Abstract |
We gave 4 days of high-dose Ara-C followed 2 days later by rHUGM-CSF (which continued until the neutrophil count was greater than 1000/microliters) to 12 patients with newly diagnosed AML and a relatively poor prognosis. Six CRs occurred, there were four deaths during induction, and in only one case was there an rHUGM-CSF-associated growth of leukemia. The pattern of hematologic recovery was variable but in some patients rHUGM-CSF seemed to accelerate normal myelopoiesis following chemotherapy. Continued investigation of rHUGM-CSF and chemotherapy in AML is warranted. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 10 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Professor | 1 | 10% |
Student > Ph. D. Student | 1 | 10% |
Student > Master | 1 | 10% |
Researcher | 1 | 10% |
Professor > Associate Professor | 1 | 10% |
Other | 0 | 0% |
Unknown | 5 | 50% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 2 | 20% |
Psychology | 2 | 20% |
Agricultural and Biological Sciences | 1 | 10% |
Unknown | 5 | 50% |