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PEGylated Protein Drugs: Basic Science and Clinical Applications

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Cover of 'PEGylated Protein Drugs: Basic Science and Clinical Applications'

Table of Contents

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    Book Overview
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    Chapter 1 Preface PEGylated protein conjugates: A new class of therapeutics for the 21st century
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    Chapter 2 Protein PEGylation, basic science and biological applications
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    Chapter 3 Reactive PEGs for protein conjugation
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    Chapter 4 Rebridging disulphides: site-specific PEGylation by sequential bis-alkylation
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    Chapter 5 Enzymatic techniques for PEGylation of biopharmaceuticals
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    Chapter 6 The site-specific TGase-mediated PEGylation of proteins occurs at flexible sites
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    Chapter 7 Protein conjugates purification and characterization
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    Chapter 8 PEG and PEG conjugates toxicity: towards an understanding of the toxicity of PEG and its relevance to PEGylated biologicals
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    Chapter 9 The occurrence, induction, specificity and potential effect of antibodies against poly(ethylene glycol)
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    Chapter 10 Pegfilgrastim — designing an improved form of rmetHuG-CSF
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    Chapter 11 PEGylation of human growth hormone: strategies and properties
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    Chapter 12 PEGylated α interferons: two different strategies to achieve increased efficacy
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    Chapter 13 Development of PEGylated mammalian urate oxidase as a therapy for patients with refractory gout
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    Chapter 14 Certolizumab pegol: a PEGylated anti-tumour necrosis factor alpha biological agent
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    Chapter 15 PEG: a useful technology in anticancer therapy
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    Chapter 16 Regulatory strategy and approval processes considered for PEG-drug conjugates and other nanomedicines
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