| Chapter title |
Sigma-1 Receptor and Neuronal Excitability
|
|---|---|
| Chapter number | 8 |
| Book title |
Sigma Proteins: Evolution of the Concept of Sigma Receptors
|
| Published in |
Handbook of experimental pharmacology, January 2017
|
| DOI | 10.1007/164_2017_8 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-965851-3, 978-3-31-965853-7
|
| Authors |
Saïd Kourrich, Kourrich, Saïd |
| Abstract |
The sigma-1 receptor (Sig-1R), via interaction with various proteins, including voltage-gated and ligand-gated ion channels (VGICs and LGICs), is involved in a plethora of neuronal functions. This capability to regulate a variety of ion channel targets endows the Sig-1R with a powerful capability to fine tune neuronal excitability, and thereby the transmission of information within brain circuits. This versatility may also explain why the Sig-1R is associated to numerous diseases at both peripheral and central levels. To date, how the Sig-1R chooses its targets and how the combinations of target modulations alter overall neuronal excitability is one of the challenges in the field of Sig-1R-dependent regulation of neuronal activity. Here, we will describe and discuss the latest findings on Sig-1R-dependent modulation of VGICs and LGICs, and provide hypotheses that may explain the diverse excitability outcomes that have been reported so far. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 16 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 6 | 38% |
| Student > Bachelor | 3 | 19% |
| Student > Master | 1 | 6% |
| Lecturer > Senior Lecturer | 1 | 6% |
| Other | 1 | 6% |
| Other | 2 | 13% |
| Unknown | 2 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 8 | 50% |
| Biochemistry, Genetics and Molecular Biology | 3 | 19% |
| Medicine and Dentistry | 2 | 13% |
| Agricultural and Biological Sciences | 1 | 6% |
| Engineering | 1 | 6% |
| Other | 0 | 0% |
| Unknown | 1 | 6% |