| Chapter title |
3D Homology Model of Sigma1 Receptor
|
|---|---|
| Chapter number | 35 |
| Book title |
Sigma Proteins: Evolution of the Concept of Sigma Receptors
|
| Published in |
Handbook of experimental pharmacology, January 2017
|
| DOI | 10.1007/164_2017_35 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-965851-3, 978-3-31-965853-7
|
| Authors |
Erik Laurini, Domenico Marson, Maurizio Fermeglia, Sabrina Pricl, Laurini, Erik, Marson, Domenico, Fermeglia, Maurizio, Pricl, Sabrina |
| Abstract |
This chapter presents the three-dimensional (3D) model of the Sigma1 receptor protein as obtained from homology modeling techniques. We show the applicability of this structure to docking-based virtual screening and discuss combined in silico/in vitro mutagenesis studies performed to validate the structural features of the Sigma1 receptor model and to qualify/quantify the prominent role of specific amino acid residues in ligand binding. The validation of the virtual 3D Sigma1 receptor model and its reliable applicability to docking-based virtual screening is of significance for rational ligand design, even in light of the recently reported crystal structure for the Sigma1 receptor. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 13 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 3 | 23% |
| Researcher | 3 | 23% |
| Lecturer > Senior Lecturer | 1 | 8% |
| Student > Ph. D. Student | 1 | 8% |
| Student > Doctoral Student | 1 | 8% |
| Other | 2 | 15% |
| Unknown | 2 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 6 | 46% |
| Chemistry | 3 | 23% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 8% |
| Computer Science | 1 | 8% |
| Chemical Engineering | 1 | 8% |
| Other | 0 | 0% |
| Unknown | 1 | 8% |