Chapter title |
Sigma-1 (σ1) Receptor in Memory and Neurodegenerative Diseases
|
---|---|
Chapter number | 15 |
Book title |
Sigma Proteins: Evolution of the Concept of Sigma Receptors
|
Published in |
Handbook of experimental pharmacology, January 2017
|
DOI | 10.1007/164_2017_15 |
Pubmed ID | |
Book ISBNs |
978-3-31-965851-3, 978-3-31-965853-7
|
Authors |
Tangui Maurice, Nino Goguadze, Maurice, Tangui, Goguadze, Nino |
Abstract |
The sigma-1 (σ1) receptor has been associated with regulation of intracellular Ca(2+) homeostasis, several cellular signaling pathways, and inter-organelle communication, in part through its chaperone activity. In vivo, agonists of the σ1 receptor enhance brain plasticity, with particularly well-described impact on learning and memory. Under pathological conditions, σ1 receptor agonists can induce cytoprotective responses. These protective responses comprise various complementary pathways that appear to be differentially engaged according to pathological mechanism. Recent studies have highlighted the efficacy of drugs that act through the σ1 receptor to mitigate symptoms associated with neurodegenerative disorders with distinct mechanisms of pathogenesis. Here, we will review genetic and pharmacological evidence of σ1 receptor engagement in learning and memory disorders, cognitive impairment, and neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis, and Huntington's disease. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 48 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 7 | 15% |
Student > Ph. D. Student | 6 | 13% |
Researcher | 6 | 13% |
Student > Doctoral Student | 2 | 4% |
Other | 2 | 4% |
Other | 8 | 17% |
Unknown | 17 | 35% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 10 | 21% |
Biochemistry, Genetics and Molecular Biology | 6 | 13% |
Medicine and Dentistry | 5 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 6% |
Chemistry | 3 | 6% |
Other | 4 | 8% |
Unknown | 17 | 35% |