Chapter title |
The Development of Prophylactic and Therapeutic EBV Vaccines.
|
---|---|
Chapter number | 16 |
Book title |
Epstein Barr Virus Volume 2
|
Published in |
Current topics in microbiology and immunology, January 2015
|
DOI | 10.1007/978-3-319-22834-1_16 |
Pubmed ID | |
Book ISBNs |
978-3-31-922833-4, 978-3-31-922834-1
|
Authors |
Smith, Corey, Khanna, Rajiv, Corey Smith, Rajiv Khanna |
Abstract |
Over the last century, the development of effective vaccine approaches to treat a number of viral infections has provided the impetus for the continual development of vaccine platforms for other viral infections, including Epstein-Barr virus (EBV). The clinical manifestations associated with EBV infection occur either following primary infection, such as infectious mononucleosis, or following an extended period of latency, primarily the EBV-associated malignancies and potentially including a number of autoimmune disorders, such as multiple sclerosis. As a consequence, two independent vaccine approaches are under development to prevent or control EBV-associated diseases. The first approach, which has been widely successful against other viral infections, is aimed at inducing a viral neutralisation antibody response to prevent primary infection. The second approach focuses upon the induction of cell-mediated immunity to control latent infected cells in persistently infected individuals. Early clinical studies have offered some insight into the potential efficacy of both of these approaches. |
X Demographics
Geographical breakdown
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 40 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 4 | 10% |
Researcher | 4 | 10% |
Student > Doctoral Student | 4 | 10% |
Student > Master | 4 | 10% |
Other | 3 | 8% |
Other | 6 | 15% |
Unknown | 15 | 38% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 7 | 18% |
Immunology and Microbiology | 4 | 10% |
Neuroscience | 3 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 5% |
Agricultural and Biological Sciences | 2 | 5% |
Other | 4 | 10% |
Unknown | 18 | 45% |