| Chapter title |
Computational Methods Involved in Evaluating the Toxicity of the Reproductive Toxicants in Sertoli Cell
|
|---|---|
| Chapter number | 18 |
| Book title |
Sertoli Cells
|
| Published in |
Methods in molecular biology, January 2018
|
| DOI | 10.1007/978-1-4939-7698-0_18 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-7697-3, 978-1-4939-7698-0
|
| Authors |
Pranitha Jenardhanan, Manivel Panneerselvam, Premendu P. Mathur, Jenardhanan, Pranitha, Panneerselvam, Manivel, Mathur, Premendu P. |
| Abstract |
The Sertoli cell, the somatic component of seminiferous tubule, provides nutritional support and immunological protection and supports overall growth and division of germ cells. Cytoskeletons, junction proteins, and kinases in Sertoli cells are prime targets for reproductive toxicants and other environmental contaminants. Among the varied targets, the kinases that are crucial for regulating varied activities in spermatogenesis such as assembly/disassembly of blood-testis barrier and apical ES and those that are involved in conferring polarity are highly targeted. In an attempt to study the effect of toxicants on these kinases, the present chapter deals with computational methodology concerning their three-dimensional structure prediction, identification of inhibitors, and understanding of conformational changes induced by these inhibitors. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 3 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Professor | 2 | 67% |
| Unknown | 1 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 1 | 33% |
| Agricultural and Biological Sciences | 1 | 33% |
| Unknown | 1 | 33% |