Chapter title |
Genetic Rodent Models of Huntington Disease
|
---|---|
Chapter number | 2 |
Book title |
Polyglutamine Disorders
|
Published in |
Advances in experimental medicine and biology, January 2018
|
DOI | 10.1007/978-3-319-71779-1_2 |
Pubmed ID | |
Book ISBNs |
978-3-31-971778-4, 978-3-31-971779-1
|
Authors |
J. Stricker-Shaver, A. Novati, L. Yu-Taeger, H. P. Nguyen |
Abstract |
The monogenic nature of Huntington disease (HD) has led to the development of a spectrum of useful genetically modified models. In particular, rodents have pioneered as the first HD model being generated and have since been the most widely used animal model for HD in both basic research and preclinical therapeutic studies. Based on the generation strategies, these rodent models can be classified into 3 major groups, the transgenic fragment models, the transgenic full-length models and the knock-in models. These models display a range of HD-like characteristics which resemble the clinical symptoms of HD patients. Their applications in research are thus regarded as an invaluable approach to speeding up the unraveling of the underlying pathological mechanisms of HD and for finding a disease-modifying treatment for this devastating disease. In this chapter, the similarities and differences of the most commonly used rodent HD models and their relevance to human HD will be compared and discussed. This also serves to guide the selection of an appropriate rodent HD model according to the nature of investigation. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 52 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 10 | 19% |
Student > Ph. D. Student | 9 | 17% |
Student > Bachelor | 4 | 8% |
Student > Master | 4 | 8% |
Other | 2 | 4% |
Other | 3 | 6% |
Unknown | 20 | 38% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 9 | 17% |
Biochemistry, Genetics and Molecular Biology | 6 | 12% |
Neuroscience | 5 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 6% |
Medicine and Dentistry | 3 | 6% |
Other | 4 | 8% |
Unknown | 22 | 42% |