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B Cell Receptor Signaling

Overview of attention for book
Cover of 'B Cell Receptor Signaling'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 Activation-Induced Cytidine Deaminase Aided In Vitro Antibody Evolution
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    Chapter 2 Analyzing Mouse B Cell Responses Specific to LCMV Infection
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    Chapter 3 Expression of Exogenous Genes in Murine Primary B Cells and B Cell Lines Using Retroviral Vectors
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    Chapter 4 Biophysical Techniques to Study B Cell Activation: Single-Molecule Imaging and Force Measurements
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    Chapter 5 DNA-Based Probes for Measuring Mechanical Forces in Cell-Cell Contacts: Application to B Cell Antigen Extraction from Immune Synapses
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    Chapter 6 Deriving Quantitative Cell Biological Information from Dye-Dilution Lymphocyte Proliferation Experiments
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    Chapter 7 Flow Cytometry Analysis of mTOR Signaling in Antigen-Specific B Cells
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    Chapter 8 Ex Vivo Culture Assay to Measure Human Follicular Helper T (Tfh) Cell-Mediated Human B Cell Proliferation and Differentiation
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    Chapter 9 B Cell Receptor Signaling and Compartmentalization by Confocal Microscopy
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    Chapter 10 Imaging the Interactions Between B Cells and Antigen-Presenting Cells
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    Chapter 11 In Vivo Tracking of Particulate Antigen Localization and Recognition by B Lymphocytes at Lymph Nodes
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    Chapter 12 Study B Cell Antigen Receptor Nano-Scale Organization by In Situ Fab Proximity Ligation Assay
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    Chapter 13 Single-Particle Tracking of Cell Surface Proteins
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    Chapter 14 The Use of Intravital Two-Photon and Thick Section Confocal Imaging to Analyze B Lymphocyte Trafficking in Lymph Nodes and Spleen
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    Chapter 15 Time-Lapse Förster Resonance Energy Transfer Imaging by Confocal Laser Scanning Microscopy for Analyzing Dynamic Molecular Interactions in the Plasma Membrane of B Cells
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    Chapter 16 Understanding of B Cell Receptor Signaling Through a Photo-Activatable Antigen Presentation System
  18. Altmetric Badge
    Chapter 17 Use of Streptolysin O-Induced Membrane Damage as a Method of Studying the Function of Lipid Rafts During B Cell Activation
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    Chapter 18 Visualization and Quantitative Analysis of the Actin Cytoskeleton Upon B Cell Activation
Attention for Chapter 8: Ex Vivo Culture Assay to Measure Human Follicular Helper T (Tfh) Cell-Mediated Human B Cell Proliferation and Differentiation
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  • Good Attention Score compared to outputs of the same age and source (66th percentile)

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Chapter title
Ex Vivo Culture Assay to Measure Human Follicular Helper T (Tfh) Cell-Mediated Human B Cell Proliferation and Differentiation
Chapter number 8
Book title
B Cell Receptor Signaling
Published in
Methods in molecular biology, January 2018
DOI 10.1007/978-1-4939-7474-0_8
Pubmed ID
29388103
Book ISBNs
978-1-4939-7473-3, 978-1-4939-7474-0
Authors

Xin Gao, Lin, Di Yu, Lin Lin

Abstract

Upon priming by antigens, B cells undergo activation, proliferation, and differentiation into antibody-secreting cells. During thymus-dependent (TD) antibody responses, the proliferation and differentiation of antigen-primed B cells essentially rely on the helper function from CD4+ T cells. Follicular helper T (Tfh) cells constitute a specialized Th subset that localizes in close proximity to B cells and supports B cell proliferation and differentiation through co-stimulatory receptors and cytokines. Impaired Tfh-mediated B cell proliferation and differentiation were observed in patients with immunodeficiency, while overactivation of this process may lead to dysregulated immune responses seen in autoimmune disorders. Here, we describe an ex vivo coculture assay using circulating Tfh cells and B cells isolated from human blood. This method can be used to examine the function of patients' B cells for proliferation, differentiation, and antibody secretion, mediated by the physiological help from Tfh cells.

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X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
 Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 27 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 19%
Student > Ph. D. Student 5 19%
Student > Bachelor 3 11%
Student > Doctoral Student 2 7%
Professor > Associate Professor 2 7%
Other 2 7%
Unknown 8 30%
Readers by discipline Count As %
Immunology and Microbiology 8 30%
Biochemistry, Genetics and Molecular Biology 4 15%
Neuroscience 3 11%
Medicine and Dentistry 3 11%
Agricultural and Biological Sciences 1 4%
Other 1 4%
Unknown 7 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 February 2018.
All research outputs
#14,374,036
of 23,020,670 outputs
Outputs from Methods in molecular biology
#4,226
of 13,166 outputs
Outputs of similar age
#240,496
of 442,354 outputs
Outputs of similar age from Methods in molecular biology
#432
of 1,498 outputs
Altmetric has tracked 23,020,670 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,166 research outputs from this source. They receive a mean Attention Score of 3.4. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 442,354 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1,498 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.

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