Chapter title |
Analysis of Circular RNAs Using the Web Tool CircInteractome
|
---|---|
Chapter number | 4 |
Book title |
Circular RNAs
|
Published in |
Methods in molecular biology, January 2018
|
DOI | 10.1007/978-1-4939-7562-4_4 |
Pubmed ID | |
Book ISBNs |
978-1-4939-7561-7, 978-1-4939-7562-4
|
Authors |
Amaresh C. Panda, Dawood B. Dudekula, Kotb Abdelmohsen, Myriam Gorospe |
Abstract |
Circular RNAs (circRNAs) are generated through nonlinear back splicing, during which the 5' and 3' ends are covalently joined. Consequently, the lack of free ends makes them very stable compared to their counterpart linear RNAs. By selectively interacting with microRNAs and RNA-binding proteins (RBPs), circRNAs have been shown to influence gene expression programs. We designed a web tool, CircInteractome, in order to (1) explore potential interactions of circRNAs with RBPs, (2) design specific divergent primers to detect circRNAs, (3) study tissue- and cell-specific circRNAs, (4) identify gene-specific circRNAs, (5) explore potential miRNAs interacting with circRNAs, and (6) design specific siRNAs to silence circRNAs. Here, we review the CircInteractome tool and explain recent updates to the site. The database is freely accessible at http://circinteractome.nia.nih.gov . |
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