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Hepatitis B Virus

Overview of attention for book
Cover of 'Hepatitis B Virus'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 NTCP-Reconstituted In Vitro HBV Infection System
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    Chapter 2 Hepatitis B Virus Infection of HepaRG Cells, HepaRG-hNTCP Cells, and Primary Human Hepatocytes
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    Chapter 3 Live Cell Imaging Confocal Microscopy Analysis of HBV Myr-PreS1 Peptide Binding and Uptake in NTCP-GFP Expressing HepG2 Cells
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    Chapter 4 Intracytoplasmic Transport of Hepatitis B Virus Capsids
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    Chapter 5 A Homokaryon Assay for Nucleocytoplasmic Shuttling Activity of HBV Core Protein
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    Chapter 6 Analyses of HBV cccDNA Quantification and Modification
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    Chapter 7 Detection of HBV cccDNA Methylation from Clinical Samples by Bisulfite Sequencing and Methylation-Specific PCR
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    Chapter 8 A T7 Endonuclease I Assay to Detect Talen-Mediated Targeted Mutation of HBV cccDNA
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    Chapter 9 Detection of Hepatocyte Clones Containing Integrated Hepatitis B Virus DNA Using Inverse Nested PCR
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    Chapter 10 Highly Sensitive Detection of HBV RNA in Liver Tissue by In Situ Hybridization
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    Chapter 11 Immunofluorescent Staining for the Detection of the Hepatitis B Core Antigen in Frozen Liver Sections of Human Liver Chimeric Mice
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    Chapter 12 Measuring Changes in Cytosolic Calcium Levels in HBV- and HBx-Expressing Cultured Primary Hepatocytes
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    Chapter 13 In Vitro Assays for RNA Binding and Protein Priming of Hepatitis B Virus Polymerase
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    Chapter 14 In Vitro Enzymatic and Cell Culture-Based Assays for Measuring Activity of HBV RNaseH Inhibitors
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    Chapter 15 Detection of Hepatitis B Virus Particles Released from Cultured Cells by Particle Gel Assay
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    Chapter 16 Microtiter-Format Assays for HBV Antigen Quantitation in Nonclinical Applications
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    Chapter 17 Deep Sequencing of the Hepatitis B Virus Genome: Analysis of Multiple Samples by Implementation of the Illumina Platform
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    Chapter 18 Generation of Replication-Competent Hepatitis B Virus Genome from Blood Samples for Functional Characterization
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    Chapter 19 Hydrodynamic HBV Transfection Mouse Model
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    Chapter 20 An ELISPOT-Based Assay to Measure HBV-Specific CD8 + T Cell Responses in Immunocompetent Mice
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    Chapter 21 Advanced Method for Isolation of Mouse Hepatocytes, Liver Sinusoidal Endothelial Cells, and Kupffer Cells
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    Chapter 22 Partial Hepatectomy and Castration of HBV Transgenic Mice
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    Chapter 23 Studying HBV Infection and Therapy in Immune-Deficient NOD-Rag1−/−IL2RgammaC-null (NRG) Fumarylacetoacetate Hydrolase (Fah) Knockout Mice Transplanted with Human Hepatocytes
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    Chapter 24 Measurement of Antiviral Effect and Innate Immune Response During Treatment of Primary Woodchuck Hepatocytes
Attention for Chapter 23: Studying HBV Infection and Therapy in Immune-Deficient NOD-Rag1−/−IL2RgammaC-null (NRG) Fumarylacetoacetate Hydrolase (Fah) Knockout Mice Transplanted with Human Hepatocytes
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Chapter title
Studying HBV Infection and Therapy in Immune-Deficient NOD-Rag1−/−IL2RgammaC-null (NRG) Fumarylacetoacetate Hydrolase (Fah) Knockout Mice Transplanted with Human Hepatocytes
Chapter number 23
Book title
Hepatitis B Virus
Published in
Methods in molecular biology, January 2017
DOI 10.1007/978-1-4939-6700-1_23
Pubmed ID
27975325
Book ISBNs
978-1-4939-6698-1, 978-1-4939-6700-1
Authors

Feng Li, Kouki Nio, Fumihiko Yasui, Christopher M. Murphy, Lishan Su

Abstract

Chimeric mouse models with a humanized liver provide a unique tool to study hepatic virus diseases, including viral infection, viral pathogenesis, and antiviral therapy. Here we describe a detailed protocol for studying hepatitis B infection in NRG-derived fumarylacetoacetate hydrolase (Fah) knockout mice repopulated with human hepatocytes. The procedures include (1) maintenance and genotyping of the homozygous NRG-fah/fah mutant mice (NRG/F), (2) intrasplenic injection of human hepatocytes, (3) NTBC drug reduction cycling to improve human hepatocyte repopulation, (4) human albumin detection, and (5) HBV infection and detection. The method is simple and allows for highly reproducible generation of NRG/F-hu Hep mice for studying HBV infection and therapy.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
 Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 6 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 6 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 3 50%
Unspecified 1 17%
Student > Postgraduate 1 17%
Unknown 1 17%
Readers by discipline Count As %
Medicine and Dentistry 2 33%
Biochemistry, Genetics and Molecular Biology 1 17%
Unspecified 1 17%
Immunology and Microbiology 1 17%
Nursing and Health Professions 1 17%
Other 0 0%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 January 2018.
All research outputs
#15,488,947
of 23,016,919 outputs
Outputs from Methods in molecular biology
#5,388
of 13,165 outputs
Outputs of similar age
#257,394
of 421,312 outputs
Outputs of similar age from Methods in molecular biology
#468
of 1,074 outputs
Altmetric has tracked 23,016,919 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,165 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 421,312 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1,074 others from the same source and published within six weeks on either side of this one. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.

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