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Non-canonical Cyclic Nucleotides

Overview of attention for book
Cover of 'Non-canonical Cyclic Nucleotides'

Table of Contents

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    Book Overview
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    Chapter 34 Mammalian Nucleotidyl Cyclases and Their Nucleotide Binding Sites
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    Chapter 35 Cyclic Nucleotide Monophosphates in Plants and Plant Signaling.
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    Chapter 36 cAMP-Dependent Protein Kinase and cGMP-Dependent Protein Kinase as Cyclic Nucleotide Effectors
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    Chapter 37 Interaction of Epac with Non-canonical Cyclic Nucleotides
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    Chapter 38 Identification of cCMP and cUMP Substrate Proteins and Cross Talk Between cNMPs.
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    Chapter 39 3',5'-cIMP as Potential Second Messenger in the Vascular Wall.
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    Chapter 40 Discovery and Roles of 2′,3′-cAMP in Biological Systems
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    Chapter 41 Medicinal Chemistry of the Noncanonical Cyclic Nucleotides cCMP and cUMP
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    Chapter 42 Holistic Methods for the Analysis of cNMP Effects
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    Chapter 43 The Chemistry of the Noncanonical Cyclic Dinucleotide 2′3′-cGAMP and Its Analogs
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    Chapter 5000 8-Nitro-cGMP: A Novel Protein-Reactive cNMP and Its Emerging Roles in Autophagy
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    Chapter 5001 Mass Spectrometric Analysis of Non-canonical Cyclic Nucleotides
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    Chapter 5002 Cyclic Dinucleotides in the Scope of the Mammalian Immune System
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    Chapter 5003 The Pseudomonas aeruginosa Exoenzyme Y: A Promiscuous Nucleotidyl Cyclase Edema Factor and Virulence Determinant
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    Chapter 5004 Inactivation of Non-canonical Cyclic Nucleotides: Hydrolysis and Transport
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    Chapter 5005 cCMP and cUMP Across the Tree of Life: From cCMP and cUMP Generators to cCMP- and cUMP-Regulated Cell Functions
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    Chapter 5006 Regulation of HCN Ion Channels by Non-canonical Cyclic Nucleotides
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    Chapter 5007 cCMP and cUMP in Apoptosis: Concepts and Methods
Attention for Chapter 39: 3',5'-cIMP as Potential Second Messenger in the Vascular Wall.
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Chapter title
3',5'-cIMP as Potential Second Messenger in the Vascular Wall.
Chapter number 39
Book title
Non-canonical Cyclic Nucleotides
Published in
Handbook of experimental pharmacology, January 2016
DOI 10.1007/164_2015_39
Pubmed ID
26721675
Book ISBNs
978-3-31-952671-3, 978-3-31-952673-7
Authors

Leung, Susan W S, Gao, Yuansheng, Vanhoutte, Paul M, Susan W. S. Leung, Yuansheng Gao, Paul M. Vanhoutte

Abstract

Traditionally, only the 3',5'-cyclic monophosphates of adenosine and guanosine (produced by adenylyl cyclase and guanylyl cyclase, respectively) are regarded as true "second messengers" in the vascular wall, despite the presence of other cyclic nucleotides in different tissues. Among these noncanonical cyclic nucleotides, inosine 3',5'-cyclic monophosphate (cIMP) is synthesized by soluble guanylyl cyclase in porcine coronary arteries in response to hypoxia, when the enzyme is activated by endothelium-derived nitric oxide. Its production is associated with augmentation of vascular contraction mediated by stimulation of Rho kinase. Based on these findings, cIMP appears to meet most, if not all, of the criteria required for it to be accepted as a "second messenger," at least in the vascular wall.

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Geographical breakdown

Country Count As %
Unknown 4 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 1 25%
Unknown 3 75%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 1 25%
Unknown 3 75%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 January 2016.
All research outputs
#20,299,108
of 22,836,570 outputs
Outputs from Handbook of experimental pharmacology
#572
of 650 outputs
Outputs of similar age
#330,608
of 393,564 outputs
Outputs of similar age from Handbook of experimental pharmacology
#51
of 55 outputs
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